Sankappa Rai, U.Isloor, A.M.Shetty, P.Isloor, N.Malladi, S.Fun, H.-K.2026-02-052010European Journal of Medicinal Chemistry, 2010, 45, 12, pp. 6090-60942235234https://doi.org/10.1016/j.ejmech.2010.09.015https://idr.nitk.ac.in/handle/123456789/27380A three-component Mannich reaction of different ketones with aromatic aldehydes and different amines in microwave irradiation under solvent free condition afforded corresponding ?-amino carbonyl compounds in excellent yields. This method proved as a novel and improved modification of the reported three-component Mannich reaction in terms of milder reaction conditions, reaction times, clean reaction profiles, very small quantity of catalyst and simple workup procedure. Newly synthesized ?-aminoketones were characterized by spectral studies. Structure of compound 4a was also confirmed by single-crystal X-ray analysis. All the compounds were screened for their antimicrobial activity by MIC method. Few of the molecules were found to be biologically potent. © 2010 Elsevier Masson SAS. All rights reserved.2 [(2 methylindol 5 ylamino)pyridin 4 yl [methyl]]cyclohexanone2 [(2,4 difluorophenylamino) [2 fluoromethoxyphenyl]methyl]cyclohexanone2 [(2,4 difluorophenylamino) [4 fluorophenyl]methyl]cyclohexanone2 [(3 fluorophenylamino) [2 [allyloxy]phenyl]methyl]cyclohexanone2 [(3 methoxyphenylamino) [2 hydroxy 3 methylphenyl]methyl]cyclohexanone2 [(3,4 difluorophenylamino) (2 fluorophenyl) methyl] cyclohexanone2 [(3,4,5 trifluorophenylamino) (4 ethylphenyl) methyl] cyclohexanone2 [(4 methyl 3 nitrophenylamino) [4 ethylphenyl]methyl]cyclohexanone2 [(4 tert butylphenylamino) [phenyl]methyl]cyclohexanone2 [(benzofuran 2 yl) [naphthalen 1 ylamino]methyl]cyclohexanone4 [(2 chlorophenyl) [2 oxocyclohexyl]methylamino]benzonitrilealdehydeaminoketoneantiinfective agentbeta aminoketoneunclassified drugantimicrobial activityarticleBacillus subtiliscatalystdrug screeningdrug structuredrug synthesisEscherichia coliMannich reactionmicrowave irradiationminimum inhibitory concentrationPseudomonas aeruginosaStaphylococcus aureusX ray analysisAnti-Bacterial AgentsCrystallography, X-RayKetonesMicrobial Sensitivity TestsMicrowavesModels, MolecularMolecular StructureStructure-Activity Relationship