Yeshwanth, G.S.Annappa, B.Dodia, S.Manoj Kumar, M.V.2026-02-062023Lecture Notes in Electrical Engineering, 2023, Vol.928, , p. 251-26118761100https://doi.org/10.1007/978-981-19-5482-5_22https://idr.nitk.ac.in/handle/123456789/29670The growth of the brain from infantile to adolescence is very complex and takes a very long period. There are many processes such as myelination, migration, neural induction, and many other time-taking processes to study the development of the brain. This makes it necessary to develop some automatic tools to study the development of the brain. The brain consists mainly of three parts white matter, gray matter, and cerebrospinal fluid. So, quantitative tools will be a great boon for the medical community to deal with the brain if the brain MRI images are segmented into these three different parts. Although there are some tools for segmenting adult MRI images, for 6-month child segmentation, the brain becomes challenging as the white matter and gray matter are almost indistinguishable due to the brain development process. Segmentation of brain MRI images can identify specific patterns that contribute to healthy brain development. The dataset to address this problem had been taken from the Iseg2019 challenge conducted by MICCAI. Segmentation of MRI needs expert doctors. Advancements in computer vision techniques can be used to replace present time-consuming work. This paper proposes a deep learning model for image segmentation using a three-dimensional U-net. The proposed model gives dice values of 93.75, 88.24, and 85.64 for cerebrospinal fluid, gray matter, and white matter. This paper also presents various experimental results of U-net, attention U-net with different modifications. © 2023, The Author(s), under exclusive license to Springer Nature Singapore Pte Ltd.Deep learningGamma transformationInfant brain MRI IsointenseSegmentationU-net