Ubaradka, S.R.Isloor, A.M.Shetty, P.Shetty, P.Isloor, N.A.2026-02-052013Medicinal Chemistry Research, 2013, 22, 3, pp. 1497-150310542523https://doi.org/10.1007/s00044-012-0103-1https://idr.nitk.ac.in/handle/123456789/26823In this study, a series of new 1,2,4-oxadiazole derivatives containing 3,4-dihydro-2H-chromen-2-amine moiety were synthesized by efficient microwave reaction of 2-amino-N?-hydroxychroman-3-carboxamidine and suitable aldehyde. Structures of all the synthesized compounds were confirmed by spectral studies and C, H, N analyses. Newly synthesized compounds were screened for their anticonvulsant and anti-inflammatory properties. Few of the compounds exhibited excellent anticonvulsant activity as compared to the standard drug Diazepam. Also compounds have exhibited moderate anti-inflammatory activity as compared to the standard drug Diclofenac sodium. © 2012 Springer Science+Business Media, LLC.1,2,4 oxadiazole derivative3,4 dihydro 3 [5 (thiazol 2 yl) 1,2,4 oxadiazol 3 yl] n [(thiazol 2 yl)methylene] 2h chromen 2 amine3,4 dihydro 3 [5 (thiophen 2 yl) 1,2,4 oxadiaozl 3 yl] n [(thiophen 2 yl)methylene] 2h chromen 2 amine3,4 dihydro n (3 phenylallylidene) 3 (5 styryl 1,2,4 oxadiazol 3 yl) 2h chromen 2 aminealdehyde derivativeamidineanticonvulsive agentantiinflammatory agentchromene derivativediazepamdiclofenacn (2 hydroxybenzylidene) 3 [5 (2 hydroxyphenyl) 1,2,4 oxadiazol 3 yl] 3,4 dihydro 2h chromen 2 aminen (3 nitrobenzylidene) 3,4 diihydro 3 [5 (3 nitrophenyl) 1,2,4 oxadiazol 3 yl] 2h chromen 2 aminen (3,4 dimethoxybenzylidene) 3,4 dihydro 3 [5 (3,4 dimethoxyphenyl) 1,2,4 oxadiazol 3 yl] 2 h chromen 2 aminen (4 bromobenzylidene) 3 [5 (4 bromophenyl) 1,2,4 oxadiazol 3 yl] 3,4 dihydro 2h chromen 2 aminen (4 chlorobenzylidene) 3 [5 (4 chlorophenyl) 1,2,4 oxadiazol 3 yl] 3,4 dihydro 2h chromen 2 aminen (4 fluoro 3 phenoxybenzylidene) 3 [5 (4 fluoro 3 phenoxyphenyl) 1,2,4 oxadiazol 3 yl] 3,4 dihydro 2h chromen 2 aminen (4 fluorobenzylidene) 3 [5 (4 fluorophenyl) 1,2,4 oxadiazol 3 yl] 3,4 dihydro 2h chromen 2 aminen (4 hydroxy 3 methoxybenzylidene) 3 [5 (4 hydroxy 3 methoxyphenyl) 1,2,4 oxadiazol 3 yl] 3,4 dihydro 2h chromen 2 aminen (5 bromo 2 fluorobenzylidene) 3 [5 (5 bromo 2 fluorophenyl) 1,2,4 oxadiazol 3 yl] 3,4 dihydro 2h chromen 2 aminen benzylidene 3,4 dihdyro 3 (5 phenyl 1,2,4 oxadiazol 3 yl) 2h chromen 2 amineunclassified druganimal experimentanimal modelanticonvulsant activityantiinflammatory activityarticlecarbon nuclear magnetic resonancecontrolled studydrug screeningdrug structuredrug synthesismalemicrowave irradiationmousen (2 chlorobenzylidene) 3 [5 (2 chlorophenyl) 1,2,4 oxadiazol 3 yl] 3,4 dihydro 2h chromen 2 aminenitrogen nuclear magnetic resonancenonhumanpaw edemaproton nuclear magnetic resonanceratstructure analysistonic clonic seizure