Sampath, V.P.Govindaraj, P.Ramasamy, R.Mohan, M.2026-02-052021Journal of Microbiology, Biotechnology and Food Sciences, 2021, 11, 3, pp. 1-20https://doi.org/10.15414/JMBFS.4066https://idr.nitk.ac.in/handle/123456789/23411Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) is a highly contagious strain of coronavirus that causes Coronavirus Disease 2019 (COVID-19) infection, which has distressed the world's health and wealth. This Global Pandemic outbreak has affected public health enormously at various customs. The investigation of SARS-CoV-2 is still at infancy; however, based on the available reports, this review gives an overview of the epidemiology, genomic landscape, diversity of SARS-CoV-2, viral genome pathogenic interactions, associating factors for COVID-19 infections, post-COVID-19, disease manifestations with their comorbidities, the major obstacles and the preventive measures along with current vaccine strategies of SARS-CoV-2. This review also summarizes all the relevant evidence of COVID-19 illness, which can provide valuable information on the SARS-CoV-2 genome and its mode of action strategies, thus delivering additional knowledge about COVID-19. © 2021. All Rights Reserved.COVID-19COVID-19 VaccinesDisease manifestationsGenetic factorsHerd immunityPost-COVIDSARS-CoV-2