Gokhale, N.Panathur, N.Udayakumar, D.Nayak, P.G.Pai, K.S.R.2026-02-052016Journal of Heterocyclic Chemistry, 2016, 53, 2, pp. 513-5240022152Xhttps://doi.org/10.1002/jhet.2403https://idr.nitk.ac.in/handle/123456789/26058Indole-quinazolinone hybrids with active amides were synthesized, characterized, and assessed for their cytotoxicity. Two molecules displayed substantial activity in sulphorhodamine B assay method. © 2015 HeteroCorporation.1 methyl 3 (4 oxo 3,4 dihydroquinazolin 2 yl) 1h indole 2 carboxylic acid1 methyl 3 (4 oxo 3,4 dihydroquinazolin 2 yl) n (3,4,5 trimethoxyphenyl) 1h indole 2 carboxamide1 methyl 3 (4 oxo 3,4 dihydroquinazolin 2 yl) n [4 (trifluoromethoxy)phenyl] 1h indole 2 carboxamide1 methyl n (2 morpholinoethyl) 3 (4 oxo 3,4 dihydroquinazolin 2 yl) 1h indole 2 carboxamide2 (1 methyl 2 (morpholine 4 carbonyl) 1h indol 3 yl)quinazolin 4(3h) one2 (5 fluoro 1 methyl 2 (morpholine 4 carbonyl) 1h indol 3 yl)quinazolin 4(3h) one5 fluoro 1 methyl 3 (4 oxo 3,4 dihydroquinazolin 2 yl) 1h indole 2 carboxylic acid5 fluoro 1 methyl 3 (4 oxo 3,4 dihydroquinazolin 2 yl) n (3,4,5 trimethoxyphenyl) 1h indole 2 carboxamideamideantimitotic agentcytotoxic agentethyl 1 methyl 1h indole 2 carboxylateethyl 1 methyl 3 (4 oxo 3,4 dihydroquinazolin 2 yl) 1h indole 2 carboxylateethyl 3 formyl 1 methyl 1h indole 2 carboxylateethyl 5 fluoro 1 methyl 1h indole 2 carboxylateethyl 5 fluoro 1 methyl 3 (4 oxo 3,4 dihydroquinazolin 2 yl) 1h indole 2 carboxylateethyl 5 fluoro 3 formyl 1 methyl 1h indole 2 carboxylateindole derivativen (3,4 difluorophenyl) 5 fluoro 1 methyl 3 (4 oxo 3,4 dihydroquinazolin 2 yl) 1h indole 2 carboxamiden (4 fluorobenzyl) 1 methyl 3 (4 oxo 3,4 dihydroquinazolin 2 yl) 1h indole 2 carboxamiden (4 fluorobenzyl) 5 fluoro 1 methyl 3 (4 oxo 3,4 dihydoquinazolin 2 yl) 1h indole 2 carboxamiden (4 methoxybenzyl) 1 methyl 3 (4 oxo 3,4 dihydroquinazolin 2 yl) 1h indole 2 carboxamiden (4 methoxybenzyl) 5 fluoro 1 methyl 3 (4 oxo 3,4 dihydroquinazolin 2 yl) 1h indole 2 carboxamiden (cyclohexylmethyl) 1 methyl 3 (4 oxo 3,4 dihydroquinazolin 2 yl) 1h indole 2 carboxamiden (cyclopropylmethyl) 1 methyl 3 (4 oxo 3,4 dihydroquinazolin 2 yl) 1h indole 2 carboxamiden (cyclopropylmethyl) 5 fluoro 1 methyl 3 (4 oxo 3,4 dihydroquinazolin 2 yl) 1h indole 2 carboxamiden cyclopropyl 1 methyl 3 (4 oxo 3,4 dihydroquinazolin 2 yl) 1h indole 2 carboxamiden cyclopropyl 5 fluoro 1 methyl 3 (4 oxo 3,4 dihydroquinazolin 2 yl) 1h indole 2 carboxamidequinazolinone derivativeunclassified drugunindexed druganimal cellantiproliferative activityapoptosisArticlecell cycle regulationcell cycle S phasecontrolled studycytotoxicitydrug designdrug screeningdrug synthesisenzyme activityenzyme inhibitionHepG2 cell linehumanhuman cellin vitro studyMCF 7 cell linemelanoma cell linenonhumanVero cell line