Garudachari, B.Isloor, A.M.Satyanarayana, M.N.Fun, H.-K.Hegde, G.2026-02-052014European Journal of Medicinal Chemistry, 2014, 74, , pp. 324-3322235234https://doi.org/10.1016/j.ejmech.2014.01.008https://idr.nitk.ac.in/handle/123456789/26519Three series of 8-trifluoromethylquinoline based 1,2,3-triazoles derivatives (5a-c, 6a-d and 7a-c) were synthesized by multi-step reactions by click chemistry approach. Synthesized compounds were characterized by spectral studies and X-ray analysis. The final compounds were screened for their in-vitro antimicrobial activity by well plate method (zone of inhibition). Compounds 5c, 6b, 8b, 11 and 12 were found to be active against tested microbial strains. The results are summarized in Tables 5 and 6. © 2014 Elsevier Ltd. All rights reserved.1,2,3 triazole derivative3 bromo 4 ethoxy 8 trifluoromethyl quinoline3 ethoxycarbonylmethoxy 6 trifluoromethyl furo [3,2 c]quinoline 2 carboxylic acid3 ethoxycarbonylmethoxy 6 trifluoromethyl furo [3,2 c]quinoline 2 carboxylic acid ester4 (1 benzyl 1h [1,2,3]triazol 4 ylmethoxy) 8 trifluoromethyl quinoline 3 carboxylic acid ethyl ester4 (1 butyl 1h [1,2,3]triazol 4 ylmethoxy) 8 trifluoromethyl quinoline 3 carboxylic acid ethyl ester4 (1 ethyl 1h [1,2,3]triazol 4 ylmethoxy) 8 trifluoromethyl quinoline 3 carboxylic acid ethyl ester4 (1 propyl 1h [1,2,3]triazol 4 ylmethoxy) 8 trifluoromethyl quinoline 3 carboxylic acid ethyl ester4 [1 (2,4 dichlorobenzyl) 1h [1,2,3]triazol 4 ylmethoxy] 8 trifluoromethyl quinoline 3 carboxylic acid ethyl ester4 [1 (4 nitrobenzyl) 1h [1,2,3]triazol 4 ylmethoxy] 8 trifluoromethyl quinoline 3 carboxylic acid ethyl ester4 [1 [2 (4 bromophenyl) 2 oxo ethyl] 1h [1,2,3]triazol 4 ylmethoxy] 8 trifluoromethyl quinoline 3 carboxylic acid ethyl ester4 [1 [2 (4 chlorophenyl) 2 oxo ethyl] 1h [1,2,3]triazol 4 ylmethoxy] 8 trifluoromethyl quinoline 3 carboxylic acid ethyl ester4 [1 [2 (4 fluorophenyl) 2 oxo ethyl] 1h [1,2,3]triazol 4 ylmethoxy] 8 trifluoromethyl quinoline 3 carboxylic acid ethyl ester4 [1 [2 (4 methoxyphenyl) 2 oxo ethyl] 1h [1,2,3]triazol 4 ylmethoxy] 8 trifluoromethyl quinoline 3 carboxylic acid ethyl ester4 ethoxy 3 (1 methyl 1h indol 5 yl) 8 triuoromethyl quinolineantibiotic agentantifungal agentciprofloxacinfluconazoleunclassified drugantibacterial activityantifungal activityarticleAspergillus flavusBacillus subtilisCandida albicansChrysosporium keratinophilumclick chemistrycontrolled studydrug potencydrug screeningdrug synthesisEscherichia coliin vitro studynonhumanone pot synthesisPseudomonas aeruginosaX ray analysis1,2,3-Triazole8-TrifluoromethylquinolineAntimicrobial activityClick chemistrySuzuki couplingAnti-Infective AgentsClick ChemistryMagnetic Resonance SpectroscopyModels, MolecularQuinolinesTriazoles