Eswaran, S.Vasudeva Adhikari, A.V.Pal, N.K.Chowdhury, I.H.2026-02-052010Bioorganic and Medicinal Chemistry Letters, 2010, 20, 3, pp. 1040-10440960894Xhttps://doi.org/10.1016/j.bmcl.2009.12.045https://idr.nitk.ac.in/handle/123456789/27504A series of 26 new quinoline derivatives carrying active pharmacophores has been synthesized and evaluated for their in vitro antituberculosis activity against Mycobacterium tuberculosis H37Rv (MTB), Mycobacterium smegmatis (MC2), and Mycobacterium fortuitum following the broth micro dilution assay method. Compounds 13e, 13i, 13k, 14a, 14c, 14i, and 14k exhibited significant minimum inhibition concentrations, when compared with first line drugs isoniazid (INH) and rifampicin (RIF) and could be ideally suited for further modifications to obtain more efficacious compounds in the fight against multi-drug resistant tuberculosis. © 2009 Elsevier Ltd. All rights reserved.antimycobacterial agentisoniazidquinoline 3 carbohydrazone derivativequinoline derivativerifampicinunclassified drugantiinfective agenthydrazone derivativeantibacterial activityarticlebroth dilutioncontrolled studydrug designdrug efficacydrug synthesisin vitro studyminimum inhibitory concentrationMycobacterium fortuitumMycobacterium smegmatisMycobacterium tuberculosisnonhumanpharmacophorecomparative studydrug effectsMycobacteriumphysiologysynthesisAnti-Bacterial AgentsDrug DesignHydrazonesQuinolines