Synthesis of functionalized benzo[1,3]dioxin-4-ones from salicylic acid and acetylenic esters and their direct amidation

Bhaskaran, R.P.Nayak, K.H.Babu, B.P.2026-02-052021RSC Advances, 2021, 11, 40, pp. 24570-24574https://doi.org/10.1039/d1ra05032jhttps://idr.nitk.ac.in/handle/123456789/23171Direct synthesis of 4H-benzo[d][1,3]dioxin-4-one derivatives from salicylic acids and acetylenic esters (both mono- and disubstituted) has been described. The reaction is mediated by CuI and NaHCO<inf>3</inf>in acetonitrile. Room temperature amidation of the synthesized 1,3-benzodioxinones with primary amines readily afforded the corresponding salicylamides in moderate to good yields. © The Royal Society of Chemistry 2021.AminesCopper compoundsEstersIodine compoundsOrganic pollutantsSodium compoundsAmidationDirect synthesisFunctionalizedPrimary aminesSalicylamidesSalicylic acidSynthesis of functionalized benzo[1,3]dioxin-4-ones from salicylic acid and acetylenic esters and their direct amidation