Smitha, A.Padikkal, J.2026-02-042022Multimedia Tools and Applications, 2022, 81, 20, pp. 29609-2963113807501https://doi.org/10.1007/s11042-022-12475-1https://idr.nitk.ac.in/handle/123456789/22484Retinal image analysis has opened up a new window for prompt diagnosis and detection of various retinal disorders. Optical Coherence Tomography (OCT) is one of the major diagnostic tools to identify retinal abnormalities related to macular disorders like Age-Related Macular Degeneration (AMD) and Diabetic Macular Edema (DME). The clinical findings include retinal layer analysis to spot the abnormalities on OCT images. Though various models are proposed over the years to diagnose these disorders automatically, an end-to-end system that performs automatic denoising, segmentation, and classification does not exist to the best of our knowledge. This paper proposes a Generative Adversarial Network (GAN) based approach for automated segmentation and classification of OCT-B scans to diagnose AMD and DME. The proposed method incorporates the integration of handcrafted Gabor features to enhance the retina layer segmentation and non-local denoising to remove speckle noise. The classification metrics of GAN are compared with existing methods. The accuracy of up to 92.42% and F1-score of 0.79 indicates that the GANs can perform well for segmentation and classification of OCT images. © 2022, The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.Generative adversarial networksImage analysisImage classificationImage segmentationOptical tomographyAge-related macular degenerationDiabetic macular edemaImage-analysisImages classificationMacular edemaOphthalmic image analyseRetinal disorderRetinal image analysisRetinal image segmentationRetinal image segmentation and classificationOphthalmology