Bhat, S.I.Das, U.K.Trivedi, D.R.2020-03-312020-03-312015Journal of Heterocyclic Chemistry, 2015, Vol.52, 4, pp.1253-125910.1002/jhet.2220https://idr.nitk.ac.in/handle/123456789/9878An efficient green protocol for the synthesis of quinazolines in the absence of solvent and catalyst has been developed. 2,4-Disubstituted quinazolines have been synthesized from three-component one-pot reactions of 2-aminoaryl ketones, orthoesters, and ammonium acetate. The present method has advantages of operational simplicity, substrate generality, clean reaction, high yields (76-94%), and moderate reaction time. The plausible mechanism of the reaction has been proposed based on the spectral characterization and single crystal X-ray analysis of isolated intermediate. 2014 HeteroCorporation.Article