Vijesh, A.M.Isloor, A.M.Prabhu, V.Ahmad, S.Malladi, S.2026-02-052010European Journal of Medicinal Chemistry, 2010, 45, 11, pp. 5460-54642235234https://doi.org/10.1016/j.ejmech.2010.07.048https://idr.nitk.ac.in/handle/123456789/27398In the present study a series of novel 2,4-disubstituted thiazole derivatives containing substituted pyrazole moiety was synthesized by the reaction of 3-Aryl-1H-pyrazole-4-carbaldehyde thiosemicarbazone with 6-Bromo/H-3-(bromoacetyl)-2H-chromen-2-one/phenacyl chloride. Structures of newly synthesized compounds were characterized by spectral studies. New compounds were screened for their antibacterial studies against Staphylococcus aureus, Bacillus subtilis, Escherichia coli and Pseudomonas aeruginosa. The results revealed that compounds 7c, 8e, and 8f having 2,5-dichlorothiophene substituent and 8c, 8d having 2,4-dichlorophenyl substituent showed significant antibacterial activity against all tested microorganisms. © 2010 Elsevier Masson SAS. All rights reserved.3 (2 bromoacetyl) 2h chromen 2 one3 (2,4 dichlorophenyl) 1h pyrazole 4 carbaldehyde [4 (2 oxo 2h chromen 3 yl) 1,3 thiazol 2 yl]hydrazone3 (2,4 dichlorophenyl) 1h pyrazole 4 carbaldehyde [4 (2,4 dichlorophenyl) 1,3 thiazol 2 yl]hydrazone3 (2,4 dichlorophenyl) 1h pyrazole 4 carbaldehyde [4 (6 bromo 2 oxo 2h chromen 3 yl) 1,3 thiazol 2 yl]hydrazone3 (2,4 dichlorophenyl) 1h pyrazole 4 carbaldehyde thiosemicarbazone3 (2,5 dichloro 3 thienyl) 1h pyrazole 4 carbaldehyde [4 (2 oxo 2h chromen 3 yl) 1,3 thiazol 2 yl]hydrazone3 (2,5 dichloro 3 thienyl) 1h pyrazole 4 carbaldehyde [4 (2,4 dichlorophenyl) 1,3 thiazol 2 yl]hydrazone3 (2,5 dichloro 3 thienyl) 1h pyrazole 4 carbaldehyde [4 (6 bromo 2 oxo 2h chromen 3 yl) 1,3 thiazol 2 yl]hydrazone3 (2,5 dichloro 3 thienyl) 1h pyrazole 4 carbaldehyde thiosemicarbazone3 (biphenyl) 1h pyrazole 4 carbaldehyde [4 (2 oxo 2h chromen 3 yl) 1,3 thiazol 2 yl]hydrazone3 [4 (methylthio)phenyl] 1h pyrazole 4 carbaldehyde [4 (2 oxo 2h chromen 3 yl) 1,3 thiazol 2 yl]hydrazone3 [4 (methylthio)phenyl] 1h pyrazole 4 carbaldehyde [4 (2,4 dichlorophenyl) 1,3 thiazol 2 yl]hydrazone3 [4 (methylthio)phenyl] 1h pyrazole 4 carbaldehyde [4 (6 bromo 2 oxo 2h chromen 3 yl) 1,3 thiazol 2 yl]hydrazone3 [4 (methylthio)phenyl] 1h pyrazole 4 carbaldehyde thiosemicarbazone3 biphenyl 4 yl 1h pyrazole 4 carbaldehyde [4 (2,4 dichlorophenyl) 1,3 thiazol 2 yl]hydrazone3 biphenyl 4 yl 1h pyrazole 4 carbaldehyde thiosemicarbazone6 bromo 3 (2 bromoacetyl) 2h chromen 2 oneantiinfective agentceftriaxonethiazole derivativeunclassified drugantibacterial activityarticleBacillus subtiliscarbon nuclear magnetic resonancecontrolled studydrug synthesisEscherichia coliheteronuclear nuclear magnetic resonancemass spectrometrynonhumanPseudomonas aeruginosaStaphylococcus aureusAnti-Bacterial AgentsMagnetic Resonance SpectroscopyMass SpectrometryMicrobial Sensitivity TestsSpectrophotometry, InfraredThiazoles