Ranganath, A.Shet, K.C.Vidyavathi, N.2026-02-052007In Silico Biology, 2007, 7, 2, pp. 169-1741386633814343207https://idr.nitk.ac.in/handle/123456789/27797Structural Genomics initiatives are generating an increasing number of protein structures with very limited biochemical characterization. Characterization of a protein's function and understanding the specific nature of a protein's binding is a critical part of both protein engineering and structure-based drug discovery. The accurate detection of binding site in these protein structures can be valuable in determining its function. As shape plays a crucial role in bimolecular recognition and function, the development of shape analysis techniques is important for understanding protein structure-function relationships. This paper describes the use of the continuous wavelet transforms (CWT) for characterizing shape features of 3D protein structures. The goal is to explore the CWT as a multiscale tool to generate rotation- and translation-invariant shape features. © 2007 IOS Press. All rights reserved.proteinaseaccuracyanalytic methodarticlebinding sitecontinuous wavelet transformcontrolled studydrug researchenzyme active siteenzyme structureHuman immunodeficiency virus 1mathematical computingmolecular recognitionnonhumannormal distributionprotein bindingprotein engineeringprotein functionprotein secondary structuresignal processingstructural genomicsvalidation studyAlgorithmsAmino AcidsBinding SitesComputer SimulationLigandsModels, ChemicalProtein BindingProtein ConformationProteinsSoftwareStructure-Activity Relationship