Sankappa Rai, U.Isloor, A.M.Shetty, P.Vijesh, A.M.Prabhu, N.Isloor, S.Thiageeswaran, M.Fun, H.-K.2026-02-052010European Journal of Medicinal Chemistry, 2010, 45, 6, pp. 2695-26992235234https://doi.org/10.1016/j.ejmech.2010.02.040https://idr.nitk.ac.in/handle/123456789/27461An efficient, microwave irradiated synthesis of novel chromeno[2,3-b]-pyrimidine derivatives was carried out. 2-Amino-3,4-dihydro-2H-chromene-3-carbonitrile was converted into imine using N,N-Dimethylacetaldehyde dimethylacetal to give the core intermediate, which was used for the preparation of chromenopyrimidine library, using acetic acid and different amine in microwave irradiation for 5 min. Structures of newly synthesized compounds were confirmed by spectral studies. Compound 6g was characterized by single crystal X-ray analysis. All the compounds were also screened for their anti-microbial activity. Few of the compounds are found to be potential antimicrobials. © 2010 Elsevier Masson SAS. All rights reserved.2 amino 3,4 dihydro 2h chromene 3 carbonitrile2 imino 2h chromene 3 carbonitrile4 (4 chlorobenzyl) 5h chromeno [2,3 d]pyrimidine5h chromeno [2,3 d]pyrimidin 4 amineacetic acidamineantiinfective agentceftriaxonen (1 benzylpiperidin 4 yl) 5h chromeno[2,3 d]pyrimidine 4 aminen (2,4 dichlorophenyl) 5h chromeno[2,3 d]pyrimidin 4 aminen (2,5 dimethylphenyl) 5h chromeno[2,3 d]pyrimidin 4 aminen (3 fluoro 4 methylphenyl) 5h chromeno[2,3 d]pyrimidin 4 aminen (5 methyl 1,3 thiazol 2 yl) 5h chromeno[2,3 d]pyrimidin 4 aminen 1 naphthyl 5h chromeno [2,3 d]pyrimidin 4 aminen [2 methyl 4 (trifluoromethyl)phenyl] 5 chromeno[2,3 d]pyrimidin 4 aminen benzyl 5h chromeno [2,3 d]pyrimidin 4 aminen tricyclo[5.2.1.03,8]dec 1 yl 5h chromeno[2,3 d]pyrimidin 4 aminen' (3 cyano 3,4 dihydro 2h chromen 2 yl) n,ndimethylimido formamidepyrimidine derivativeunclassified drugantimicrobial activityarticlecontrolled studydrug potencydrug screeningdrug synthesismicrowave irradiationnonhumanspectroscopystructure activity relationX ray analysisAnti-Infective AgentsBacteriaBenzopyransPyrimidinesNovel chromeno [2,3-b]-pyrimidine derivatives as potential anti-microbial agents