Nayak, K.H.Jijin, R.K.Sreelekha, M.K.Babu, B.P.2026-02-042024Organic and Biomolecular Chemistry, 2024, 22, 32, pp. 6631-663714770520https://doi.org/10.1039/d4ob00825ahttps://idr.nitk.ac.in/handle/123456789/21010A copper-catalyzed aerobic [3 + 2] annulation reaction to access various pyrazole-bound chalcones starting from readily available and cost-effective hydrazones and dienones is reported. These pyrazole-bound chalcones were further utilized effectively to prepare a series of pyrazole-linked hybrid molecules, such as pyrazole-pyrazoline, pyrazole-aziridine, and pyrazole-pyridine hybrids by efficient simple transformations. Synthetically challenging hybrid molecules were obtained in a simple, two-step process with high atom economy under aerobic copper catalysis. © 2024 The Royal Society of Chemistry.CopperCost effectivenessMoleculesAnnulation reactionsChalconesCopper catalyzedCost effectiveDienonesHybrid moleculesHydrazonesPyrazolesPyrazolinesSimple++Catalysischalcone derivativecopperhydrazone derivativepyrazolepyridineannulation reactionarticlecatalysiscontrolled studydrug analysisdrug developmenthuman tissuehybrid