Thomas, K.D.Vasudeva Adhikari, A.V.Telkar, S.Chowdhury, I.H.Mahmood, R.Pal, N.K.Guru Row, T.N.G.Sumesh, E.2026-02-052011European Journal of Medicinal Chemistry, 2011, 46, 11, pp. 5283-52922235234https://doi.org/10.1016/j.ejmech.2011.07.033https://idr.nitk.ac.in/handle/123456789/27160Three new series of 4-hydroxy-8-trifluoromethyl-quinoline derivatives were synthesized through multi step reactions. All the newly synthesized compounds were characterized by spectral and elemental analyses. The structure of 5j was evidenced by X-ray crystallographic study. The newly synthesized title compounds were evaluated for their antimicrobial activities including antimycobacterial activity. Amongst the tested compounds, 5b, 5e, 5h, 5j, 6c and 7c displayed promising antimicrobial activity. The mode of action of these active compounds was carried out by docking of receptor enoyl-ACP reductase with newly synthesized candidate ligands, 5b, 5e, 5h, 5j and 6c. © 2011 Elsevier Masson SAS. All rights reserved.2 [[4 hydroxy 8 (trifluoromethyl)quinolin 3 yl]carbonyl n (4 methoxyphenyl)hydrazinecarboxamide2 [[4 hydroxy 8 (trifluoromethyl)quinolin 3 yl]carbonyl] n (4 methylphenyl)hydrazinecarbothioamide2 [[4 hydroxy 8 (trifluoromethyl)quinolin 3 yl]carbonyl] n (4 methylphenyl)hydrazinecarboxamide2 [[4 hydroxy 8 (trifluoromethyl)quinolin 3 yl]carbonyl] n (pyridin 3 yl)hydrazinecarbothioamide2 [[4 hydroxy 8 (trifluoromethyl)uinoline 3 yl]carbonyl] n (4 methoxyphenyl)hydrazinecarbothioamide4 hydroxy 8 trifluoromethyl quinoline 3 carboxylic acid (1 methyl 1h benzotriazol 5 ylmethylene)hydrazide4 hydroxy 8 trifluoromethyl quinoline 3 carboxylic acid (1 methyl 1h pyrrol 2 ylmethylene)hydrazide4 hydroxy 8 trifluoromethyl quinoline 3 carboxylic acid (2 fluoro 4 methoxy benzylidene)hydrazide4 hydroxy 8 trifluoromethyl quinoline 3 carboxylic acid (2 methylsulfanyl benzylidene)hydrazide4 hydroxy 8 trifluoromethyl quinoline 3 carboxylic acid (3 hydroxy 4 methoxy benzylidene)hydrazide4 hydroxy 8 trifluoromethyl quinoline 3 carboxylic acid (3h imidazol 4 ylmethylene)hydrazide4 hydroxy 8 trifluoromethyl quinoline 3 carboxylic acid (4 methoxy benzylidene)hydrazide4 hydroxy 8 trifluoromethyl quinoline 3 carboxylic acid (5 fluoro 2 hydroxy benzylidene)hydrazide4 hydroxy 8 trifluoromethyl quinoline 3 carboxylic acid (5 methoxy 1h indol 3 ylmethylene)hydrazide4 hydroxy 8 trifluoromethyl quinoline 3 carboxylic acid (5 methyl 3h imidazol 4 ylmethylene)hydrazide4 hydroxy 8 trifluoromethyl quinoline 3 carboxylic acid (7 methyl 1h indol 3 ylmethylene)hydrazide4 hydroxy 8 trifluoromethyl quinoline 3 carboxylic acid [4 (1,1,2,2 tetrafluoro ethoxy) benzylidene]hydrazide4 hydroxy 8 trifluoromethyl quinoline 3 carboxylic acid benzo[1,2,5]oxadiazol 5 ylmethylene hydrazide4 hydroxy 8 trifluoromethyl quinoline 3 carboxylic acid benzofuran 5 ylmethylene hydrazide4 hydroxy 8 trifluoromethyl quinoline 3 carboxylic acid pyridin 4 ylmethylene hydrazide4 hydroxy n' [(e) (4 methylphenyl)methylidene] 8 (trifluoromethyl)quinoline 3 carbohydrazideacetic acid 4 [(4 hydroxy 8 trifluoromethyl quinoline 3 carbonyl)hydrazonomethyl] furan 2 ylmethylesterhydrazide derivativen (2 fluorophenyl) 2 [[4 hydroxy 8 (trifluoromethyl)quinolin 3 yl]carbonyl]hydrazinecarbothioamiden (3 chlorophenyl) 2 [[4 hydroxy 8 (trifluoromethyl)quinolin 3 yl]carbonyl]hydrazinecarbothioamiden (3 chlorophenyl) 2 [[4 hydroxy 8 (trifluoromethyl)quinolin 3 yl]carbonyl]hydrazinecarboxamiden (3,5 dimethylphenyl) 2 [[4 hydroxy 8 (trifluoromethyl)quinolin 3 yl]carbonyl]hydrazinecarboxamiden (4 ethylphenyl) 2 [[4 hydroxy 8 (trifluoromethyl)quinolin 3 yl]carbonyl]hydrazinecarboxamidequinoline derivativetuberculostatic agentunclassified drugantimicrobial activityarticledrug designdrug structuredrug synthesisin vitro studyX ray crystallographyAntitubercular AgentsBacteriaDrug DesignHydrazinesMicrobial Sensitivity TestsModels, MolecularMolecular ConformationQuinolines