Please use this identifier to cite or link to this item: https://idr.nitk.ac.in/jspui/handle/123456789/13310
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dc.contributor.authorIsloor, A.M.
dc.contributor.authorSunil, D.
dc.contributor.authorShetty, P.
dc.contributor.authorMalladi, S.
dc.contributor.authorPai, K.S.R.
dc.contributor.authorMaliyakkl, N.
dc.date.accessioned2020-03-31T08:45:35Z-
dc.date.available2020-03-31T08:45:35Z-
dc.date.issued2013
dc.identifier.citationMedicinal Chemistry Research, 2013, Vol.22, 2, pp.758-767en_US
dc.identifier.urihttp://idr.nitk.ac.in/jspui/handle/123456789/13310-
dc.description.abstractThere are limited studies centring on the potential of thiazolidin-4-ones as anticancer agents. In this study, a new series of 2-(3-substituted-1H- pyrazol-4-yl)-3-(3-substituted-5-sulfanyl-1,2,4-triazol-4-yl)-1, 3-thiazolidin-4-one (4a-o) have been synthesized by cyclo-condensation reaction of 5-substituted-4-[(3-substituted-1H-pyrazol-4-ylmethylidene)amino]-2H-1,2,4- triazole-3-thione (3a-o) and thioglycolic acid. The structures of all the synthesized compounds were confirmed by elemental analysis, spectral techniques like IR, 1H NMR, and mass spectroscopy. Few compounds exhibited dose-dependent cytotoxic effect in MTT assay in human breast cancer (MCF-7) cells. Apoptotic degradation of DNA due to action of potent thiazolidin-4-ones was analysed by agarose gel electrophoresis and visualized by ethidium bromide staining (comet assay). A concentration-dependent increase in tail length and olive tail moment was observed when treated with thiazolidin-4-ones. In vitro antioxidant studies like DPPH and ABTS-free radical scavenging assays-indicated moderate activity of thiazolidin-4-ones. 2012 Springer Science+Business Media, LLC.en_US
dc.titleSynthesis, characterization, anticancer, and antioxidant activity of some new thiazolidin-4-ones in MCF-7 cellsen_US
dc.typeArticleen_US
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