Please use this identifier to cite or link to this item: https://idr.nitk.ac.in/jspui/handle/123456789/13283
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dc.contributor.authorUlloora, S.
dc.contributor.authorShabaraya, R.
dc.contributor.authorRanganathan, R.
dc.contributor.authorAdhikari, A.V.
dc.date.accessioned2020-03-31T08:45:31Z-
dc.date.available2020-03-31T08:45:31Z-
dc.date.issued2013
dc.identifier.citationEuropean Journal of Medicinal Chemistry, 2013, Vol.70, , pp.341-349en_US
dc.identifier.urihttp://idr.nitk.ac.in/jspui/handle/123456789/13283-
dc.description.abstractThe present work involves design and synthesis of new substituted 1,4-dihydropyridin-4-yl-phenoxyacetohydrazones (4a-s, 5a-h), starting from 4-hydroxybenzaldehyde. The final compounds were screened for their in vivo anticonvulsant activity by MES, scPTZ and 6 Hz methods, while their anti-inflammatory screening was performed by Carrageenan induced Paw Edema method. The results indicated that compounds carrying electron donating groups are anticonvulsant active, while most of the tested compounds exhibited significant anti-inflammatory activity. Compounds 4k, l, 4p-s, and 5c showed rapid anti-inflammatory activity within 30 min and appeared as lead compounds. Further, Neurotoxicity study revealed that all the tested compounds are non-toxic up to 300 mg/kg doses. Selected compounds were also subjected to analgesic screening following Tail immersion method and they exhibited good activity. 2013 Elsevier Masson SAS. All rights reserved.en_US
dc.titleSynthesis, anticonvulsant and anti-inflammatory studies of new 1,4-dihydropyridin-4-yl-phenoxyacetohydrazonesen_US
dc.typeArticleen_US
Appears in Collections:1. Journal Articles

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