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Title: Synthesis of some new pyrazolone derivatives as potent antimicrobial agents
Authors: Vijesh, A.M.
Isloor, A.M.
Isloor, S.
Shivananda, K.N.
Shyma, P.C.
Arulmoli, T.
Issue Date: 2011
Citation: Der Pharma Chemica, 2011, Vol.3, 4, pp.454-463
Abstract: Invasive microbial infections are major problems around the world, especially in immuno compromised patients. The recent expansion of antimicrobial drug research has occurred because there is a critical need for new antimicrobial agents to treat these life threatening invasive infections. In the present study three series of new substituted pyrazolone derivatives (5a-f, 6a-f and 8a,b) were synthesized by the Knoevenagel condensation reaction of pyrazolones (3a,b) with various substituted carbaldehydes (4a-f, 7). These newly synthesized compounds were characterized by IR, NMR, mass spectra and also by C, H, N analyses. New compounds were screened for their antimicrobial studies against S. aureus, B. subtilis, E. coli and P. aeruginosa. The results revealed that compounds 5c and 6c having 2,5-dichlorothiophene substituent showed significant antibacterial activity against all tested microorganisms as compared to the standard drug Ceftriaxone.
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