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dc.contributor.authorSankappa, Rai, U.
dc.contributor.authorIsloor, A.M.
dc.contributor.authorShetty, P.
dc.contributor.authorPai, K.S.R.
dc.contributor.authorFun, H.K.
dc.identifier.citationArabian Journal of Chemistry, 2015, Vol.8, 3, pp.317-321en_US
dc.description.abstractSynthesis and characterization of new heterocyclic pyrazole chalcones (4a-. e) and diamide (6a-. e) derivatives are described. Pyrazole chalcones were synthesized by the reaction of pyrazole aldehydes and suitable aromatic ketones. Diamides were synthesized by the reaction of phthalic acid and amines. Newly synthesized compounds were characterized by spectral studies and their biological activity was assessed in vitro using MCF-7 (human breast adenocarcinoma) and HeLa (human cervical tumor cells) cell lines. Few of the synthesized molecules inhibited the growth of the human breast cancer cell lines and human cervical tumor cell lines at low micromolar to nanomolar concentrations. 2014 King Saud University.en_US
dc.titleSynthesis and in vitro biological evaluation of new pyrazole chalcones and heterocyclic diamides as potential anticancer agentsen_US
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