Please use this identifier to cite or link to this item:
Title: Synthesis and in vitro biological evaluation of new pyrazole chalcones and heterocyclic diamides as potential anticancer agents
Authors: Sankappa, Rai, U.
Isloor, A.M.
Shetty, P.
Pai, K.S.R.
Fun, H.K.
Issue Date: 2015
Citation: Arabian Journal of Chemistry, 2015, Vol.8, 3, pp.317-321
Abstract: Synthesis and characterization of new heterocyclic pyrazole chalcones (4a-. e) and diamide (6a-. e) derivatives are described. Pyrazole chalcones were synthesized by the reaction of pyrazole aldehydes and suitable aromatic ketones. Diamides were synthesized by the reaction of phthalic acid and amines. Newly synthesized compounds were characterized by spectral studies and their biological activity was assessed in vitro using MCF-7 (human breast adenocarcinoma) and HeLa (human cervical tumor cells) cell lines. Few of the synthesized molecules inhibited the growth of the human breast cancer cell lines and human cervical tumor cell lines at low micromolar to nanomolar concentrations. 2014 King Saud University.
Appears in Collections:1. Journal Articles

Files in This Item:
There are no files associated with this item.

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.