Please use this identifier to cite or link to this item: https://idr.nitk.ac.in/jspui/handle/123456789/13202
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dc.contributor.authorMalladi, S.-
dc.contributor.authorIsloor, A.M.-
dc.contributor.authorPeethambar, S.K.-
dc.contributor.authorGanesh, B.M.-
dc.contributor.authorGoud, P.S.K.-
dc.date.accessioned2020-03-31T08:45:23Z-
dc.date.available2020-03-31T08:45:23Z-
dc.date.issued2012-
dc.identifier.citationDer Pharma Chemica, 2012, Vol.4, 1, pp.43-52en_US
dc.identifier.urihttp://idr.nitk.ac.in/jspui/handle/123456789/13202-
dc.description.abstractA series of new 4,6-disubstituted-3-cyano-2-pyridone derivatives (4a-o) were synthesized. The structures of all target molecules (4a-o) have been confirmed by various spectral techniques and elemental analyses. The newly synthesized compounds were screened for antibacterial and antifungal activity and most of the compounds showed significant activity comparable with that of the standard drug. The results revealed that 4b, 4c, 4d, 4g, 4m, 4n and 4o showed good antibacterial activity towards all bacterial strains (Escherichia coli, Staphylococcus aureus and Pseudomonas aeruginosa) when compared to standard drug streptomycin. Amongst all the compounds, 4c showed moderate antifungal activity against Aspergillus flavus. The acute toxicity study has also been carried out for biologically active compounds and the experimental studies revealed that compounds were safe up to 2000 mg/kg and no deaths of animals were recorded.en_US
dc.titleSynthesis and antimicrobial activity of some new pyrazole containing cyanopyridone derivativesen_US
dc.typeArticleen_US
Appears in Collections:1. Journal Articles

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