Please use this identifier to cite or link to this item: https://idr.nitk.ac.in/jspui/handle/123456789/13195
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dc.contributor.authorUlloora, S.
dc.contributor.authorAdhikari, A.V.
dc.contributor.authorShabaraya, R.
dc.date.accessioned2020-03-31T08:45:22Z-
dc.date.available2020-03-31T08:45:22Z-
dc.date.issued2013
dc.identifier.citationChinese Chemical Letters, 2013, Vol.24, 9, pp.853-856en_US
dc.identifier.urihttp://idr.nitk.ac.in/jspui/handle/123456789/13195-
dc.description.abstractIn this manuscript, we report the synthesis of newly designed imidazo[1,2-a]pyridines carrying active pharmacophores as potential anticonvulsant agents. Newly synthesized target compounds were characterized by FTIR, 1H NMR, 13C NMR, and mass spectroscopy followed by elemental analysis studies. Preliminary anticonvulsant screening study of target compounds was carried out following MES and scPTZ methods. Compounds 6e and 6f, possessing electron rich aryl substituent at position-2 and tolyl substituted oxazolone moiety at the position-3 of imidazo[1,2-a]pyridine ring, exhibited activity comparable to standard drug diazepam and emerged as lead compounds. New compounds displayed enhanced activity in scPTZ method, indicating their ability to raise the seizure threshold. Their neurotoxicity study by Rotarod test showed that they are nontoxic at all tested doses. 2013 Elsevier B.V. All rights reserved.en_US
dc.titleSynthesis and antiepileptic studies of new imidazo[1,2-a]pyridine derivativesen_US
dc.typeArticleen_US
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