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| DC Field | Value | Language |
|---|---|---|
| dc.contributor.author | Gopkumar, P. | |
| dc.contributor.author | Mugeraya, G. | |
| dc.date.accessioned | 2020-03-31T08:39:22Z | - |
| dc.date.available | 2020-03-31T08:39:22Z | - |
| dc.date.issued | 2010 | |
| dc.identifier.citation | Research Journal of Pharmaceutical, Biological and Chemical Sciences, 2010, Vol.1, 3, pp.826-831 | en_US |
| dc.identifier.uri | http://idr.nitk.ac.in/jspui/handle/123456789/12482 | - |
| dc.description.abstract | In the present study, the fungal biotransformation of 1, 2, 3, 9-tetra hydrpyrrolo [2, 1-b] quinazolin-3-ol (I) is presented. Biocatalysis, isolation and subsequent structure elucidation of the newly transformed metabolite (-)-3-hydroxy -2, 3-dihydro pyrrolo [2, 1-b] quinazoline-9(1H)-one (II) is presented. Microbial transformation of Vasicine (I) by Aspergillus niger, Rhizopus arrhizus, Pencillium notatum and Trematus versicolor afforded (-)-3-hydroxy -2, 3-dihydro pyrrolo [2, 1-b] quinazoline-9(1H)-one (II) (100%) as the sole metabolic product. 1, 2, 3, 9-tetra hydrpyrrolo [2, 1-b] quinazolin-3-ol (I) and (-)-3-hydroxy -2, 3-dihydro pyrrolo [2, 1-b] quinazoline-9(1H)-one (II) screened for antibacterial and antifungal activity. | en_US |
| dc.title | Microbial transformation of bioactive natural products | en_US |
| dc.type | Article | en_US |
| Appears in Collections: | 1. Journal Articles | |
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