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Title: Novel chromeno [2,3-b]-pyrimidine derivatives as potential anti-microbial agents
Authors: Sankappa, Rai, U.
Isloor, A.M.
shetty, P.
Vijesh, A.M.
Prabhu, N.
Isloor, S.
Thiageeswaran, M.
Fun, H.-K.
Issue Date: 2010
Citation: European Journal of Medicinal Chemistry, 2010, Vol.45, 6, pp.2695-2699
Abstract: An efficient, microwave irradiated synthesis of novel chromeno[2,3-b]-pyrimidine derivatives was carried out. 2-Amino-3,4-dihydro-2H-chromene-3-carbonitrile was converted into imine using N,N-Dimethylacetaldehyde dimethylacetal to give the core intermediate, which was used for the preparation of chromenopyrimidine library, using acetic acid and different amine in microwave irradiation for 5 min. Structures of newly synthesized compounds were confirmed by spectral studies. Compound 6g was characterized by single crystal X-ray analysis. All the compounds were also screened for their anti-microbial activity. Few of the compounds are found to be potential antimicrobials. 2010 Elsevier Masson SAS. All rights reserved.
Appears in Collections:1. Journal Articles

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