Please use this identifier to cite or link to this item:
Title: New imidazo[1,2-a]pyridines carrying active pharmacophores: Synthesis and anticonvulsant studies
Authors: Ulloora, S.
Shabaraya, R.
Aamir, S.
Adhikari, A.V.
Issue Date: 2013
Citation: Bioorganic and Medicinal Chemistry Letters, 2013, Vol.23, 5, pp.1502-1506
Abstract: Five new series of imidazo[1,2-a]pyridines carrying biologically active pyrazoline (4a-e), cyanopyridone (5a, b), cyanopyridine (6a-f), 2-aminopyrimidine (7a-f) and pyrimidine-2-thione (8a-d) systems were designed and synthesized as prominent anticonvulsant agents. The target compounds were screened for their in vivo anticonvulsant activity following maximal electroshock (MES) and subcutaneous pentylene tetrazole (scPTZ) methods at a small test dose of 10 mg/kg. Further, Rotarod toxicity method was used to study the toxicity profile of selected compounds. Compounds 4b, 5a, 5b, 6a, 7e and 8d possessing 4-fluorophenyl substituent at 2nd position of imidazo[1,2-a]pyridine ring displayed potent anticonvulsant activity without displaying any toxicity. Enhanced activity profile was observed for new compounds in PTZ method over MES method. 2012 Elsevier Ltd. All rights reserved.
Appears in Collections:1. Journal Articles

Files in This Item:
There are no files associated with this item.

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.