Please use this identifier to cite or link to this item:
Full metadata record
DC FieldValueLanguage
dc.contributor.authorVijesh, A.M.-
dc.contributor.authorIsloor, A.M.-
dc.contributor.authorPeethambar, S.K.-
dc.contributor.authorShivananda, K.N.-
dc.contributor.authorArulmoli, T.-
dc.contributor.authorIsloor, N.A.-
dc.identifier.citationEuropean Journal of Medicinal Chemistry, 2011, Vol.46, 11, pp.5591-5597en_US
dc.description.abstractIn the present study two new series of Hantzsch 1,4-dihydropyridine derivatives (1,4-DHPs) containing substituted pyrazole moiety (4a-f and 5a-f) were synthesized by the reaction of 3-aryl-1H-pyrazole-4-carbaldehydes with 1,3-dicarbonylcompounds (ethylacetoacetate and methylacetoacetate) and ammonium acetate. The newly synthesized compounds were characterized by IR, NMR, mass spectral study and also by C, H, N analyses. New compounds were screened for their antimicrobial activity by well plate method (zone of inhibition). Antioxidant studies of the synthesized compounds were also performed by measuring the DPPH radical scavenging assay. Compounds 4c, 4e and 4f were found to be potent antibacterial and antioxidant agents. The acute oral toxicity study for the compounds 4c, 4e and 4f were carried out and the experimental studies revealed that compounds 4c and 4e is safe up to 3000 mg/kg and no death of animals were recorded. However in compound 4f, we found mortality above 2000 mg and also significant behavioral changes in experimental animals. 2011 Elsevier Masson SAS. All rights reserved.en_US
dc.titleHantzsch reaction: Synthesis and characterization of some new 1,4-dihydropyridine derivatives as potent antimicrobial and antioxidant agentsen_US
Appears in Collections:1. Journal Articles

Files in This Item:
File Description SizeFormat 
11450.pdf209.96 kBAdobe PDFThumbnail

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.