New 1,3-oxazolo[4,5-c]quinoline derivatives: Synthesis and evaluation of antibacterial and antituberculosis properties
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Date
2010
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Abstract
A new class of fused oxazoloquinoline derivatives was synthesized starting from 2-bromo-1-phenylethanones 1a-b through multi-step reactions. The newly synthesized compounds were evaluated for their in vitro antibacterial against Escherichia coli (ATTC-25922), Staphylococcus aureus (ATTC-25923), Pseudomonas aeruginosa (ATCC-27853) and Klebsiella pneumoniae (recultured) and antituberculosis activity against Mycobacterium tuberculosis H37Rv (ATCC 27294). Preliminary results indicated that most of the compounds demonstrated very good antibacterial and antituberculosis activities which are comparable with the first line drugs. Compounds 6a, 6c, 6g, 6j, 6k and 6n emerged as the lead antitubercular agents with MIC, 1 ?g/mL and 99% bacterial inhibition while eight compounds, viz., 5a, 15k, 6a, 6c, 6g, 6j, 6k and 6n were found to be more potent than INH (MIC: 1.5 ?g/mL) with MIC 1 ?g/mL. © 2009 Elsevier Masson SAS. All rights reserved.
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Keywords
1 [2 (3 fluorophenyl) 4 hydroxyquinolin 3 yl] 3 (2 methoxyphenyl)urea, 1 [2 (4 fluorophenyl) 4 hydroxyquinolin 3 yl] 3 (2 methoxyphenyl)urea, 1,3 oxazolo[4,5 c]quinoline, 4 (3 fluorophenyl) n (2 methoxyphenyl)[1,3]oxazolo[4,5 c]quinolin 2 amine, 4 (3 fluorophenyl) n (4 fluorophenyl)[1,3]oxazolo[4,5 c]quinolin 2 amine, 4 (4 fluorophenyl) n (2 methoxyphenyl)[1,3]oxazolo[4,5 c]quinolin 2 amine, isoniazid, n benzyl 4 (3 fluorophenyl)[1,3]oxazolo[4,5 c]quinolin 2 amine, n benzyl 4 (4 fluorophenyl)[1,3]oxazolo[4,5 c]quinolin 2 amine, n,4 bis (4 fluorophenyl)[1,3]oxazolo[4,5 c]quinolin 2 amine, quinoline derivative, rifampicin, tuberculostatic agent, unclassified drug, antibacterial activity, article, controlled study, drug effect, drug efficacy, drug inhibition, drug potency, drug structure, drug synthesis, Escherichia coli, Klebsiella pneumoniae, minimum inhibitory concentration, Mycobacterium tuberculosis, nonhuman, Pseudomonas aeruginosa, Staphylococcus aureus, structure activity relation, X ray crystallography, Anti-Bacterial Agents, Antitubercular Agents, Crystallography, X-Ray, Microbial Sensitivity Tests, Models, Molecular, Molecular Structure, Oxazoles, Quinolines
Citation
European Journal of Medicinal Chemistry, 2010, 45, 3, pp. 957-966