Substituted quinoline derivatives as potent biological agents

Abstract

Quinoline derivatives are the most promising class of active pharmaceutical agents compared with other heterocyclic compounds. Biological activity profile of quinoline can easily be controlled by introducing some active pharmacophore to the core ring. This chapter deals with the synthesis of quinoline derivatives and its biological activity. The enhancement of biological activity by incorporation of active functional group and effect of these functional groups were explained briefly. Main focus is given to the synthesis of different substituted quinoline derivatives for biological application with respect to the position on the quinoline core ring and modification of quinoline ring. © (2014) Trans Tech Publications, Switzerland.