Synthesis of new 3-aryl-4-(3-aryl-4,5-dihydro-1H-pyrazol-5-yl)-1-phenyl-1H- pyrazole derivatives as potential antimicrobial agents

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dc.contributor.authorMalladi, S.
dc.contributor.authorIsloor, A.M.
dc.contributor.authorPeethambar, S.K.
dc.contributor.authorFun, H.-K.
dc.date.accessioned2026-02-05T09:34:46Z
dc.date.issued2013
dc.description.abstractNew (E)-1-aryl-3-(3-aryl-1-phenyl-1H-pyrazol-4-yl)prop-2-en-1-ones 6 (pyrazolic chalcones) were synthesized from Claisen-Schmidt reaction of 3-aryl-1-phenylpyrazol-4-carboxaldehydes 4 with several acetophenone derivatives 5. Subsequently, the cyclocondensation reaction of chalcones 6 with phenylhydrazine in acetic acid medium afforded the new 3-aryl-4-(3-aryl-4,5- dihydro-1H-pyrazol-5-yl)-1-phenyl-1H-pyrazoles 7. The synthesized compounds were characterized by spectral studies and evaluated for their in vitro antibacterial activity against three pathogenic bacterial strains, Staphylococcus aureus, Escherichia coli, and Pseudomonas aeruginosa, and in vitro antifungal activity against three pathogenic fungal strains Aspergillus flavus, Chrysosporium keratinophilum, and Candida albicans. © 2012 Springer Science+Business Media New York.
dc.identifier.citationMedicinal Chemistry Research, 2013, 22, 6, pp. 2654-2664
dc.identifier.issn10542523
dc.identifier.urihttps://doi.org/10.1007/s00044-012-0267-8
dc.identifier.urihttps://idr.nitk.ac.in/handle/123456789/26780
dc.subject3 (4 bromophenyl) 1 phenyl 4 (1 phenyl 3 biphenyl 4,5 dihydro 1h pyrazol 5 yl) 1h pyrazole
dc.subject3 (4 bromophenyl) 4 [3 (2,4 dichlorophenyl) 1 phenyl 4,5 dihydro 1h pyrazol 5 yl] 1 pheny 1h pyrazole
dc.subject3 (4 bromophenyl) 4 [3 [4 (methylthio)phenyl] 1 phenyl 4,5 dihydro 1h pyrazol 5 yl] 1 phenyl 1h pyrazole
dc.subject3 (4 chlorophenyl) 1 phenyl 4 (1 phenyl 3 biphenyl 4,5 dihydro 1h pyrazol 5 yl) 1h pyrazole
dc.subject3 (4 chlorophenyl) 4 [3 (2,4 dichlorophenyl) 1 phenyl 4,5 dihydro 1h pyrazol 5 yl] 1 pheny 1h pyrazole
dc.subject3 (4 chlorophenyl) 4 [3 [4 (methylthio)phenyl] 1 phenyl 4,5 dihydro 1h pyrazol 5 yl] 1 phenyl 1h pyrazole
dc.subject3 (4 methoxyphenyl) 1 phenyl 4 (1 phenyl 3 biphenyl 4,5 dihydro 1h pyrazol 5 yl) 1h pyrazole
dc.subject3 (4 methoxyphenyl) 4 [3 [4 (methylthio)phenyl] 1 phenyl 4,5 dihydro 1h pyrazol 5 yl] 1 phenyl 1h pyrazole
dc.subject3 aryl 4 (3 aryl 4,5 dihydro 1h pyrazol 5 yl) 1 phenyl 1h pyrazole derivative
dc.subject4 [3 (2,4 dichlorophenyl) 1 phenyl 4,5 dihydro 1h pyrazol 5 yl] 1,3 diphenyl 1h pyrazole
dc.subject4 [3 (2,4 dichlorophenyl) 1 phenyl 4,5 dihydro 1h pyrazol 5 yl] 3 (4 methoxyphenyl) 1 phenyl 1h pyrazole
dc.subject4 [3 [4 (methylthio)phenyl] 1 phenyl 4,5 dihydro 1h pyrazol 5 yl] 1,3 dipheyl 1h pyrazole
dc.subjectantibiotic agent
dc.subjectantifungal agent
dc.subjectfluconazole
dc.subjectpyrazole derivative
dc.subjectstreptomycin
dc.subjectunclassified drug
dc.subjectantibacterial activity
dc.subjectantifungal activity
dc.subjectarticle
dc.subjectAspergillus flavus
dc.subjectCandida albicans
dc.subjectchrysosporium keratinophilum
dc.subjectcontrolled study
dc.subjectdrug synthesis
dc.subjectEscherichia coli
dc.subjectfungus
dc.subjectin vitro study
dc.subjectinfrared spectroscopy
dc.subjectnonhuman
dc.subjectproton nuclear magnetic resonance
dc.subjectPseudomonas aeruginosa
dc.subjectStaphylococcus aureus
dc.titleSynthesis of new 3-aryl-4-(3-aryl-4,5-dihydro-1H-pyrazol-5-yl)-1-phenyl-1H- pyrazole derivatives as potential antimicrobial agents

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