Regioselective reaction: Synthesis, characterization and pharmacological studies of some new Mannich bases derived from 1,2,4-triazoles
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Date
2009
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Abstract
In the present investigation, a series of new 4[(3-substituted-1H-pyrazol-4-yl)methyleneamino]-5-substituted-2-[(4-methylpiperzine-1-yl)methyl]-2H-1,2,4-triazole-3(4H)-thiones (4) were synthesized by the aminomethylation of 4-(3-substituted-1H-pyrazol-3-yl)methyleneamino-5-substituted-4H-1,2,4-triazole-3-thiols (3) with formaldehyde and N-methylpiperzine. These newly synthesized Schiff and Mannich bases were characterized by IR, 1H NMR, mass spectral data and elemental analyses. These compounds were screened for their antibacterial and antifungal activity. Some of the compounds were found to exhibit significant antimicrobial activity. © 2009 Elsevier Masson SAS. All rights reserved.
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1 methylpiperazine, 1,2,4 triazole derivative, 2 [(4 methylpiperazin 1 yl)methyl] 2h 1,2,4 triazole 3(4h) thione derivative, formaldehyde, Mannich base, nitrofural, piperazine derivative, unclassified drug, antifungal activity, antimicrobial activity, article, drug synthesis, mass spectrometry, minimum inhibitory concentration, nonhuman, proton nuclear magnetic resonance, reaction analysis, stereochemistry, structure activity relation, Anti-Bacterial Agents, Anti-Infective Agents, Antifungal Agents, Bacteria, Candida albicans, Mannich Bases, Microbial Sensitivity Tests, Structure-Activity Relationship, Triazoles
Citation
European Journal of Medicinal Chemistry, 2009, 44, 9, pp. 3784-3787