A continuous flow microreactor as a practical tool for the synthesis of active pharmaceutical ingredients

Abstract

Continuous flow processing has become a key technology to maximize the capabilities of chemical syntheses. Numerous new tactics have been devised to synthesize various chemicals including active pharmaceutical ingredients (APIs) via a continuous flow system using microreactors. This review aims to illustrate the holistic system approach and diverse applications of continuous flow microreactors for the synthesis of APIs (with respect to type, design, and fabrication). This review also highlights the applicability of continuous flow microreactors in the synthesis of APIs in contrast to conventional batch-type methods along with a discussion of their merits and demerits. Overall, this review is expected to offer valuable insights into the utility of continuous flow microreactor technology for the upscaled production of commercially feasible APIs. © 2024 The Institution of Chemical Engineers