Progress in Electrochemical Trifluoromethylation Reactions

Abstract

The importance of fluorinated organic molecules in drugs and pharmaceuticals led to the development of several synthetic methods for introducing fluorine into bioactive molecules and trifluoromethylation is one of the key approaches for the same. Electrochemical organic synthesis has emerged as one of the most sustainable, green synthetic strategies in recent years and new developments in electroorganic synthesis also focus on electrochemical trifluoromethylation of organic compounds. A considerable number of reports have appeared in recent literature and this review surveys all the recent developments in electrochemical trifluoromethylation reactions. This highly sustainable trifluoromethylating protocol will emerge further soon and pave the way for more energy-efficient and green protocols. (Figure presented.). © 2020 Wiley-VCH GmbH