Automatic identification of diabetic maculopathy stages using fundus images

Abstract

Diabetes mellitus is a major cause of visual impairment and blindness. Twenty years after the onset of diabetes, almost all patients with type 1 diabetes and over 60% of patients with type 2 diabetes will have some degree of retinopathy. Prolonged diabetes retinopathy leads to maculopathy, which impairs the normal vision depending on the severity of damage of the macula. This paper presents a computer-based intelligent system for the identification of clinically significant maculopathy, non-clinically significant maculopathy and normal fundus eye images. Features are extracted from these raw fundus images which are then fed to the classifier. Our protocol uses feed-forward architecture in an artificial neural network classifier for classification of different stages. Three different kinds of eye disease conditions were tested in 350 subjects. We demonstrated a sensitivity of more than 95% for these classifiers with a specificity of 100%, and results are very promising. Our systems are ready to run clinically on large amounts of datasets. © 2009 Informa Healthcare USA, Inc.