Hybrid Plasmonic Circular Aperture Waveguide for Blood Glucose Sensing

Abstract

A novel approach for blood glucose (or blood sugar) sensing utilizing a hybrid plasmonic circular aperture waveguide (HPCAW)-based nanostructure is proposed. The reported sensor combines the unique optical properties of plasmonic waveguides and circular aperture to achieve higher sensitivity and specificity in glucose detection. The HPCAW structure is designed to efficiently confine and propagate surface plasmon polaritons (SPPs) along the circular aperture, enabling enhanced light-matter interaction within the sensing region. Through rigorous numerical simulations and validation, we demonstrate the superior performance of the HPCAW sensor in terms of sensitivity (391.72 nm/RIU), figure of merit (FOM) (7.08 RIU-1), and detection accuracy (DA) (0.018 nm-1) compared to conventional glucose sensing techniques. Moreover, the proposed sensor offers inherent advantages, such as label-free detection, compact footprint, and compatibility with microfluidic systems. HPCAW provides a promising platform for the next-generation blood glucose monitoring applications with potential clinical translation. 1558-1748 © 2024 IEEE.