Metal-Free Bisamidation of N-Tosylhydrazones with Carboxylic Acids Promoted by Tetrabutylammonium Iodide and tert-Butyl Hydroperoxide

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dc.contributor.authorShamnad, A.
dc.contributor.authorNayak, K.H.
dc.contributor.authorBabu, B.P.
dc.date.accessioned2026-02-04T12:24:50Z
dc.date.issued2024
dc.description.abstractA versatile reaction between N-tosylhydrazones and carboxylic acids to access bisamides is reported. This metal-free, room-temperature reaction was catalyzed by TBAI, while TBHP served as the oxidant. Broad substrate scope and good functional group tolerance are the key features of the strategy. Subsequent intramolecular N-arylation of suitably substituted bisamides readily afforded functionalized 3-indazolones. © 2024 American Chemical Society
dc.identifier.citationJournal of Organic Chemistry, 2024, 89, 9, pp. 6545-6554
dc.identifier.issn223263
dc.identifier.urihttps://doi.org/10.1021/acs.joc.4c00156
dc.identifier.urihttps://idr.nitk.ac.in/handle/123456789/21137
dc.publisherAmerican Chemical Society
dc.subjectFunctionalized
dc.subjectKey feature
dc.subjectMetal free
dc.subjectN-arylations
dc.subjectN-tosylhydrazones
dc.subjectTert-butylhydroperoxide
dc.subjectCarboxylic acids
dc.subjectcarboxylic acid
dc.subjectfunctional group
dc.subjecthydrazone derivative
dc.subjectindazole derivative
dc.subjecttert butyl hydroperoxide
dc.subjecttetrabutylammonium
dc.subjecttoluenesulfonic acid derivative
dc.subjectamidation
dc.subjectArticle
dc.subjectarylation
dc.subjectcatalysis
dc.subjectcontrolled study
dc.subjectquantum yield
dc.subjectreaction analysis
dc.subjectreaction optimization
dc.titleMetal-Free Bisamidation of N-Tosylhydrazones with Carboxylic Acids Promoted by Tetrabutylammonium Iodide and tert-Butyl Hydroperoxide

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