New pyrazole derivatives containing 1,2,4-triazoles and benzoxazoles as potent antimicrobial and analgesic agents
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Date
2013
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Abstract
Azole class of compounds are well known for their excellent therapeutic properties. Present paper describes about the synthesis of three series of new 1,2,4-triazole and benzoxazole derivatives containing substituted pyrazole moiety (11a-d, 12a-d and 13a-d). The newly synthesized compounds were characterized by spectral studies and also by C, H, N analyses. All the synthesized compounds were screened for their analgesic activity by the tail flick method. The antimicrobial activity of the new derivatives was also performed by Minimum Inhibitory Concentration (MIC) by the serial dilution method. The results revealed that the compound 11c having 2,5-dichlorothiophene substituent on pyrazole moiety and a triazole ring showed significant analgesic and antimicrobial activity. © 2012 Elsevier Masson SAS. All rights reserved.
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Keywords
analgesic agent, antibiotic agent, antifungal agent, benzoxazole derivative, ceftriaxone, fluconazole, pentazocine, pyrazole derivative, analgesic activity, animal experiment, animal model, antibacterial activity, antifungal activity, article, Bacillus subtilis, Candida albicans, carbon nuclear magnetic resonance, controlled study, dilution, drug screening, drug synthesis, Escherichia coli, male, minimum inhibitory concentration, nitrogen nuclear magnetic resonance, nonhuman, proton nuclear magnetic resonance, Pseudomonas aeruginosa, rat, Staphylococcus aureus, tail flick test, Analgesics, Animals, Anti-Bacterial Agents, Antifungal Agents, Bacteria, Benzoxazoles, Dose-Response Relationship, Drug, Fungi, Microbial Sensitivity Tests, Molecular Structure, Pain, Pain Measurement, Pyrazoles, Rats, Rats, Wistar, Structure-Activity Relationship, Triazoles
Citation
European Journal of Medicinal Chemistry, 2013, 62, , pp. 410-415