Synthesis, characterization and antimicrobial studies of some new pyrazole incorporated imidazole derivatives

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dc.contributor.authorVijesh, A.M.
dc.contributor.authorIsloor, A.M.
dc.contributor.authorTelkar, S.
dc.contributor.authorPeethambar, S.K.
dc.contributor.authorRai, S.
dc.contributor.authorIsloor, N.
dc.date.accessioned2026-02-05T09:35:46Z
dc.date.issued2011
dc.description.abstractIn the present study two series of novel imidazole derivatives containing substituted pyrazole moiety (3a-d and 5a-j) were synthesized. The first series were synthesized by the reaction of 3-aryl-1H-pyrazole-4-carbaldehyde thiosemicarbazones (2a-d) with DMAD and the second series by the reaction of 3-aryl-1H-pyrazole-4-carbaldehydes (1a-e) with 1,2-diketones (4a,b) in the presence of ammonium acetate. Structures of newly synthesized compounds were characterized by spectral studies. New compounds were screened for antifungal and antibacterial activities. Among the synthesized compounds, compound 3c was found to be potent antimicrobial agent. The acute oral toxicity study for the compound 3c was carried out and the experimental studies revealed that compound 3c is safe up to 3000 mg/kg and no death of animals were recorded. © 2011 Elsevier Masson SAS. All rights reserved.
dc.identifier.citationEuropean Journal of Medicinal Chemistry, 2011, 46, 8, pp. 3531-3536
dc.identifier.issn2235234
dc.identifier.urihttps://doi.org/10.1016/j.ejmech.2011.05.005
dc.identifier.urihttps://idr.nitk.ac.in/handle/123456789/27216
dc.subject3 (2,4 dichlorophenyl) 4 (4,5 diphenyl 1h imidazol 2 yl) 1h pyrazole
dc.subject3 (2,5 dichlorothiophen 3 yl) 4 (4,5 diphenyl 1h imidazol 2 yl) 1h pyrazole
dc.subject3 (biphenyl 4 yl) 4 (4,5 diphenyl 1h imidazol 2 yl) 1h pyrazole
dc.subject3 (biphenyl 4 yl) 4 [4,5 bis(4 bromophenyl) 1h imidazol 2 yl] 1h pyrazole
dc.subject4 (4,5 diphenyl 1h imidazol 2 yl) 3 (4 methylphenyl) 1h pyrazole
dc.subject4 (4,5 diphenyl 1h imidazol 2 yl) 3 [4 (methylsulfanyl)phenyl] 1h pyrazole
dc.subject4 [4,5 bis(4 bromophenyl) 1h imidazol 2 yl] 3 (2,4 dichlorophenyl) 1h pyrazole
dc.subject4 [4,5 bis(4 bromophenyl) 1h imidazol 2 yl] 3 (2,5 dichlorothiophen 3 yl) 1h pyrazole
dc.subject4 [4,5 bis(4 bromophenyl) 1h imidazol 2 yl] 3 (4 methylphenyl) 1h pyrazole
dc.subject4 [4,5 bis(4 bromophenyl) 1h imidazol 2 yl] 3 [4 (methylsulfanyl)phenyl] 1h pyrazole
dc.subjectantiinfective agent
dc.subjectfluconazole
dc.subjectimidazole derivative
dc.subjectm ethyl 2 [5 oxo 2 thioxo 3 [[3 (4 tolyl)] 1h pyrazol 4 yl]methyleneamino]imidazolidin 4 ylidene)acetate
dc.subjectmethyl 2 [3 [[3 (2,4 dichlorophenyl) 1h pyrazol 4 yl]methyleneamino] 5 oxo 2 thioxoimidazolidin 4 ylidene]acetate
dc.subjectmethyl 2 [3 [[3 (2,5 dichlorothiophen 3 yl) 1h pyrazol 4 yl]methyleneamino] 5 oxo 2 thioxoimidazolidin 4 ylidene]acetate
dc.subjectmethyl 2 [3 [[3 [4 (methylthio)phenyl] 1h pyrazol 4 yl]methyleneamino] 5 oxo 2 thioxoimidazolidin 4 ylidene]acetate
dc.subjectpyrazole derivative
dc.subjectunclassified drug
dc.subjectanimal behavior
dc.subjectanimal experiment
dc.subjectantibacterial activity
dc.subjectantifungal activity
dc.subjectArthroderma gypseum
dc.subjectarticle
dc.subjectAspergillus flavus
dc.subjectAspergillus niger
dc.subjectBacillus subtilis
dc.subjectCandida albicans
dc.subjectClostridium perfringens
dc.subjectconcentration response
dc.subjectdrug potency
dc.subjectdrug safety
dc.subjectdrug structure
dc.subjectdrug synthesis
dc.subjectEscherichia coli
dc.subjectfemale
dc.subjectin vitro study
dc.subjectmouse
dc.subjectnonhuman
dc.subjectPseudomonas aeruginosa
dc.subjectSalmonella typhimurium
dc.subjectStaphylococcus aureus
dc.subjectstructure activity relation
dc.subjectTrichophyton rubrum
dc.subjectAdministration, Oral
dc.subjectAnimals
dc.subjectAnti-Infective Agents
dc.subjectBacterial Infections
dc.subjectFemale
dc.subjectFungi
dc.subjectGram-Negative Bacteria
dc.subjectGram-Positive Bacteria
dc.subjectImidazoles
dc.subjectMaximum Tolerated Dose
dc.subjectMice
dc.subjectMicrobial Sensitivity Tests
dc.subjectMolecular Structure
dc.subjectMycoses
dc.subjectPyrazoles
dc.titleSynthesis, characterization and antimicrobial studies of some new pyrazole incorporated imidazole derivatives

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