Enhancing glucose detection: Vanadium-doped TiO2 (V0.07Ti0.93O2) as non-enzymatic biosensor

Abstract

Humans need glucose as a source of energy, but abnormal glucose levels can have a negative influence on health. Elevated blood glucose levels are a common symptom of conditions like diabetes, which can cause problems with the kidneys, nerves, and cardiovascular system. For precise glucose monitoring and control, reliable glucose biosensors are essential. In a recent study, we synthesized Vanadium-doped TiO<inf>2</inf> (V<inf>0.07</inf>Ti<inf>0.93</inf>O<inf>2</inf>) using the solvothermal method. This material underwent thorough SEM and XRD investigations to characterize it before being coated over nickel foam (NF) to fabricate a non-enzymatic glucose biosensor. Notably, our research shows that this biosensor outperforms the Ag/AgCl electrode at 0.6 V with improved cyclic electrochemical stability and more effective glucose oxidation using the electrochemical workstation. The material has a sensitivity of 1482.8 μA.mM−1 cm−2 and has a broad linear range spanning 0.2 mM to 2 mM. The biosensor has extraordinary sensitivity, providing accurate glucose detection even at lower concentrations, with a limit of detection (LOD) at 0.488 mM and a limit of quantification (LOQ) at 1.629 mM. These results highlight the biosensor’s potential for reliable and precise glucose sensing, a crucial benefit for continuous glucose monitoring, especially for individuals with diabetes. © The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2024.