Metal-free Synthesis of Trisubstituted Pyrazoles by the Reaction Between Hydrazones and Activated Olefins
| dc.contributor.author | Bhaskaran, R.P. | |
| dc.contributor.author | Sreelekha, M.K. | |
| dc.contributor.author | Babu, B.P. | |
| dc.date.accessioned | 2026-02-04T12:27:30Z | |
| dc.date.issued | 2022 | |
| dc.description.abstract | The reactivity of various activated olefins towards the [3+2] annulation with hydrazones (aza-enamines) has been studied. Nitroolefins, methyl vinyl ketone, acrylates and acrylamide were found to react with aldehyde hydrazones of different electronic nature to generate 1,3,5-/1,3,4–trisubstituted pyrazoles selectively. A detailed optimization study was conducted to derive the best condition for the annulation reaction of different olefin partner and the intermediate dihydropyrazole is also identified. © 2022 Wiley-VCH GmbH. | |
| dc.identifier.citation | ChemistrySelect, 2022, 7, 44, pp. - | |
| dc.identifier.uri | https://doi.org/10.1002/slct.202202773 | |
| dc.identifier.uri | https://idr.nitk.ac.in/handle/123456789/22314 | |
| dc.publisher | John Wiley and Sons Inc | |
| dc.subject | Acrylate | |
| dc.subject | Hydrazone | |
| dc.subject | Methyl vinyl ketone | |
| dc.subject | Nitroolefin | |
| dc.subject | Pyrazole | |
| dc.subject | [3+2] annulation | |
| dc.title | Metal-free Synthesis of Trisubstituted Pyrazoles by the Reaction Between Hydrazones and Activated Olefins |