Anti-diarrheal potential of Aegle Marmelos Corr. root bark extract in rats
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Date
2007
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Abstract
A study was undertaken to evaluate the effect of methanolic extract of the rootbark of Aegle marmelos Corr. (MAMC) against several experimental models of diarrhoea in rats. MAMC treated animal's showed significant inhibitory effect against castor-oil induced diarrhea and PGE<inf>2</inf> induced enteropooling in rats. The extract also showed a significant reduction in gastrointestinal motility in the charcoal meal test in rats. The results obtained to establish the efficacy and substantiate the folkare claim as an anti-diarrhoeal agent.
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Keywords
Aegle marmelos extract, atropine, castor oil, diphenoxylate, methanol, prostaglandin E2, animal experiment, animal model, animal tissue, article, bark, controlled study, diarrhea, drug dose comparison, drug efficacy, drug mechanism, drug screening, female, gastrointestinal motility, LD 50, male, nonhuman, plant root, rat, toxicity testing, Wistar rat
Citation
Pharmacologyonline, 2007, 3, , pp. 1-14