Synthesis and in vitro biological evaluation of new pyrazole chalcones and heterocyclic diamides as potential anticancer agents

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dc.contributor.authorSankappa Rai, U.
dc.contributor.authorIsloor, A.M.
dc.contributor.authorShetty, P.
dc.contributor.authorPai, K.S.R.
dc.contributor.authorFun, H.-K.
dc.date.accessioned2026-02-05T09:33:50Z
dc.date.issued2015
dc.description.abstractSynthesis and characterization of new heterocyclic pyrazole chalcones (4a-. e) and diamide (6a-. e) derivatives are described. Pyrazole chalcones were synthesized by the reaction of pyrazole aldehydes and suitable aromatic ketones. Diamides were synthesized by the reaction of phthalic acid and amines. Newly synthesized compounds were characterized by spectral studies and their biological activity was assessed in vitro using MCF-7 (human breast adenocarcinoma) and HeLa (human cervical tumor cells) cell lines. Few of the synthesized molecules inhibited the growth of the human breast cancer cell lines and human cervical tumor cell lines at low micromolar to nanomolar concentrations. © 2014 King Saud University.
dc.identifier.citationArabian Journal of Chemistry, 2015, 8, 3, pp. 317-321
dc.identifier.issn18785352
dc.identifier.urihttps://doi.org/10.1016/j.arabjc.2014.01.018
dc.identifier.urihttps://idr.nitk.ac.in/handle/123456789/26306
dc.publisherElsevier B.V.
dc.subjectAmines
dc.subjectBioactivity
dc.subjectCell culture
dc.subjectCells
dc.subjectKetones
dc.subjectLanthanum compounds
dc.subjectSpectroscopic analysis
dc.subjectTumors
dc.subjectDiamides
dc.subjectEDCI
dc.subjectHeLa
dc.subjectHOBt
dc.subjectMCF 7
dc.subjectSynthesis (chemical)
dc.titleSynthesis and in vitro biological evaluation of new pyrazole chalcones and heterocyclic diamides as potential anticancer agents

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