Synthesis, characterization and biological activity of some new 1,3,4-oxadiazole bearing 2-flouro-4-methoxy phenyl moiety

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dc.contributor.authorChandrakantha, B.
dc.contributor.authorShetty, P.
dc.contributor.authorNambiyar, V.
dc.contributor.authorIsloor, N.
dc.contributor.authorIsloor, A.M.
dc.date.accessioned2026-02-05T09:36:26Z
dc.date.issued2010
dc.description.abstractIn the present study a series of new 1,3,4-oxadiazole derivatives containing 2-fluoro-4-methoxy moiety were synthesized. These newly synthesized compounds were characterized by NMR, mass spectral, IR spectral study and also by C, H, N analyses. All the newly synthesized compounds were screened for their antibacterial and antifungal studies. Antimicrobial studies revealed that compounds 4a and 4b showed significant antibacterial activity against Escherichia coli and Pseudomonas aeruginosa Compound 4i showed significant antifungal activity against C. albicans. © 2009 Elsevier Masson SAS. All rights reserved.
dc.identifier.citationEuropean Journal of Medicinal Chemistry, 2010, 45, 3, pp. 1206-1210
dc.identifier.issn2235234
dc.identifier.urihttps://doi.org/10.1016/j.ejmech.2009.11.046
dc.identifier.urihttps://idr.nitk.ac.in/handle/123456789/27492
dc.subject1,3,4 oxadiazole derivative
dc.subject2 (2 bromo 5 chlorophenyl) 5 (2 fluoro 4 methoxyphenyl) 1,3,4 oxadiazole
dc.subject2 (2 fluoro 4 methoxyphenyl) 5 (2,3,4 trifluorophenyl) 1,3,4 oxadiazole
dc.subject2 (2 fluoro 4 methoxyphenyl) 5 (3 fluoro 4 nitrophenyl) 1,3,4 oxadiazole
dc.subject2 (2 fluoro 4 methoxyphenyl) 5 (5 methylisoxazol 3 yl) 1,3,4 oxadiazole
dc.subject2 (2 fluoro 4 methoxyphenyl) 5 [2 (trifluoromethyl)phenyl] 1,3,4 oxadiazole
dc.subject2 (2,3 difluoro 6 nitrophenyl) 5 (2 fluoro 4 methoxyphenyl) 1,3,4 oxadiazole
dc.subject2 (2,3 dimethylphenyl) 5 (2 fluoro 4 methoxyphenyl) 1,3,4 oxadiazole
dc.subject2 (3 bromo 2 methylphenyl) 5 (2 fluoro 4 methoxyphenyl) 1,3,4 oxadiazole
dc.subject2 (3,5 difluorophenyl) 5 (2 fluoro 4 methoxyphenyl) 1,3,4 oxadiazole
dc.subject2 (4 fluorophenyl) 5 (2 fluoro 4 methoxyphenyl) 1,3,4 oxadiazole
dc.subject2 chloro 5 [5 (2 fluoro 4 methoxyphenyl) 1,3,4 oxadiazol 2 yl]pyridine
dc.subject3 [5 (2 fluoro 4 methoxyphenyl) 1,3,4 oxadiazol 2 yl]benzonitrile
dc.subject3 [5 (2 fluoro 4 methoxyphenyl) 1,3,4 oxadiazol 2 yl]quinoline
dc.subjectantifungal agent
dc.subjectantiinfective agent
dc.subjectbenzene derivative
dc.subjectfluconazole
dc.subjectnitrofural
dc.subjectunclassified drug
dc.subjectantibacterial activity
dc.subjectantifungal activity
dc.subjectarticle
dc.subjectBacillus subtilis
dc.subjectbiological activity
dc.subjectCandida albicans
dc.subjectcontrolled study
dc.subjectdrug synthesis
dc.subjectEscherichia coli
dc.subjectinfrared spectroscopy
dc.subjectmass spectrometry
dc.subjectnonhuman
dc.subjectproton nuclear magnetic resonance
dc.subjectPseudomonas aeruginosa
dc.subjectStaphylococcus aureus
dc.subjectAnti-Bacterial Agents
dc.subjectAnti-Infective Agents
dc.subjectBacteria
dc.subjectFluorine
dc.subjectFungi
dc.subjectMagnetic Resonance Spectroscopy
dc.subjectMicrobial Sensitivity Tests
dc.subjectMolecular Structure
dc.subjectOxadiazoles
dc.subjectSpectrophotometry, Infrared
dc.titleSynthesis, characterization and biological activity of some new 1,3,4-oxadiazole bearing 2-flouro-4-methoxy phenyl moiety

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