A novel series of homoallylic amines as potential antimicrobials

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dc.contributor.authorRai, U.S.
dc.contributor.authorIsloor, A.M.
dc.contributor.authorShetty, P.
dc.contributor.authorIsloor, N.
dc.contributor.authorPadaki, M.
dc.contributor.authorFun, H.-K.
dc.date.accessioned2026-02-05T09:35:18Z
dc.date.issued2012
dc.description.abstractAn efficient catalytic three-component reaction of aldehydes, amines, and allyltributylstannate has been successfully developed to produce homoallylic amines at 25°C, in excellent yields, in the presence of 1 mol% of trifluoroacetic acid an inexpensive and environmentally friendly catalyst. Newly synthesized compounds were confirmed by spectral studies. Compound 3o was characterized by single crystal X-ray analysis. All the compounds were also screened for their antimicrobial activity. Halogen-substituted compounds namely 3d, 3g, 3n, and 3o have showed excellent antibacterial activity. © Springer Science+Business Media, LLC 2011.
dc.identifier.citationMedicinal Chemistry Research, 2012, 21, 7, pp. 1090-1097
dc.identifier.issn10542523
dc.identifier.urihttps://doi.org/10.1007/s00044-011-9607-3
dc.identifier.urihttps://idr.nitk.ac.in/handle/123456789/26994
dc.subject(1 benzofuran 2 yl but 3 eny) napthalen 1 yl amine
dc.subject(1 benzofuran 2 yl but enyl) (3,5 difluoro benzyl) amine
dc.subject(1 cyclohexyl but 3 enyl) (2,5 dimethyl phenyl) amine
dc.subject(1 cyclohexyl but 3 enyl) (4 morpholin 4 yl phenyl) amine
dc.subject(1 cyclopropyl but 3 enyl) (4 fluoro 3 trifluoromethylphenyl) amine
dc.subject(2,4 difluoro phenyl) [1(2,4 difluoro phenyl) but 3 enyl] amine
dc.subject(4 chloro 2 fluoro phenyl) [1(2,6 difluoro phenyl) but 3 enyl] amine
dc.subject(4 tert butyl phenyl) (1 cyclopropyl 3 but enyl) amine
dc.subject(4 tert butyl phenyl) [1(2,4 difluoro phenyl) but 3 eny] amine
dc.subject1[3(1 (benzothiazol 7 ylamino) but 3 enyl) indol 1 yl] ethanone
dc.subject4(1 thiophen 2 yl butylamino) benzonitrile
dc.subject[1(2 allyloxy phenyl) but 3 enyl][4(4 chloro phenoxy) phenyl] amine
dc.subject[1(2 fluoro 6 methoxy phenyl) but 3 enyl] (3 fluorophenyl) amine
dc.subject[1(2,4 diflurophenyl) but 3 enyl] (2,4,5-trifluorophenyl) amine
dc.subject[1(3 chloro phenyl) but enyl] (3 ethoxy phenyl) amine
dc.subject[4(4 chloro phenoxy) phenyl] [1(5(2 chloro phenyl) furan 2 yl) but 3 enyl] amine
dc.subjectaldehyde
dc.subjectallyltributylstannate
dc.subjectamine
dc.subjectantiinfective agent
dc.subjectceftriaxone
dc.subjecthalogen
dc.subjecthomoallylic amine
dc.subjectnaphthalene1 y (1 phenyl but 3 enyl) amine
dc.subjecttrifluoroacetic acid
dc.subjectunclassified drug
dc.subjectantibacterial activity
dc.subjectarticle
dc.subjectcontrolled study
dc.subjectdrug screening
dc.subjectdrug structure
dc.subjectdrug synthesis
dc.subjectin vitro study
dc.subjectminimum inhibitory concentration
dc.subjectnonhuman
dc.subjectX ray crystallography
dc.titleA novel series of homoallylic amines as potential antimicrobials

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