Synthesis, characterization and biological activities of some new benzo[b]thiophene derivatives
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2010
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Abstract
Benzo[b]thiophene molecules are found to be important tools in synthetic medicinal chemistry. They are of current interest due to their wide spectrum of pharmacological properties. In view of the biological activities of benzo[b]thiophene containing molecules, in this present research work, we propose the synthesis of some new benzo[b]thiophene derivatives such as thiadiazoles, oxadiazoles, pyrazolin & diaryl pyrazoles starting from 3-chlorobenzo[b]thiophene-2-carboxyl chloride. These newly synthesized compounds were characterized by elemental analyses, I.R, NMR and Mass spectral studies. Some of the selected compounds were screened for their antibacterial, antifungal and anti-inflammatory studies. Many of the molecules were found to be potent. © 2009 Elsevier Masson SAS. All rights reserved.
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(n 1 aroyloxyacetyl) n 2 (3 chlorobenzo[b]thiophene 2carboxyl)hydrazine, 1 (3 chlorobenzo[b]thiophene 3carbonyl) 3,5 diaryl pyrazole derivative, 2 [3 chloro 2benzo[b]thiophenyl] 5 aryloxymethyl 1,3,4 oxadiazole, 3 chlorobenzo[b]thiophene 2 carboxyl chloride, 3 chlorobenzo[b]thiophene 2 carboxylhydrazine, 3 chlorobenzo[b]thiophene 2 methyl carboxylate, antifungal agent, antiinfective agent, antiinflammatory agent, benzothiophene derivative, carrageenan, diclofenac, ethyl 2 aryl hydrazono 3 oxobutyrate, gum arabic, oxadiazole derivative, phenazone, pyrazole derivative, thiadiazole derivative, unclassified drug, animal experiment, animal model, antibacterial activity, antifungal activity, antiinflammatory activity, antimicrobial activity, article, biological activity, carbon nuclear magnetic resonance, controlled study, drug screening, drug structure, drug synthesis, infrared radiation, infrared spectroscopy, mass spectrometry, nonhuman, proton nuclear magnetic resonance, rat, Animals, Anti-Infective Agents, Anti-Inflammatory Agents, Bacteria, Drug Evaluation, Preclinical, Edema, Fungi, Rats, Rats, Wistar, Spectrum Analysis, Thiophenes
Citation
European Journal of Medicinal Chemistry, 2010, 45, 2, pp. 825-830