A highly efficient and green cascade synthesis of 3-methyl-substituted-4- hydroxy-1-methyl-quinolin-2(1H)-ones under solvent- and catalyst-free conditions
| dc.contributor.author | Bhat, S.I. | |
| dc.contributor.author | Trivedi, D.R. | |
| dc.date.accessioned | 2026-02-05T09:34:17Z | |
| dc.date.issued | 2014 | |
| dc.description.abstract | An expeditious and green protocol for the synthesis of 3,3?- methanediylbis(4-hydroxy-1-methylquinolin-2(1H)-one) (MDBHQ) derivatives and 3-((2-amino-6-oxocyclohex-1-enyl)methyl)-4-hydroxy-1-methylquinolin-2(1H)-one (AOCHQ) derivatives has been developed via a cascade Knoevenagel-Michael reaction. The products were obtained in high yield under neat reaction conditions without any work-up or chromatographic purification. The generality and functional tolerance of this environmentally benign protocol is demonstrated. © 2014 The Royal Society of Chemistry. | |
| dc.identifier.citation | RSC Advances, 2014, 4, 22, pp. 11300-11304 | |
| dc.identifier.uri | https://doi.org/10.1039/c3ra45208e | |
| dc.identifier.uri | https://idr.nitk.ac.in/handle/123456789/26527 | |
| dc.title | A highly efficient and green cascade synthesis of 3-methyl-substituted-4- hydroxy-1-methyl-quinolin-2(1H)-ones under solvent- and catalyst-free conditions |