Synthesis, anticonvulsant and anti-inflammatory studies of new 1,4-dihydropyridin-4-yl-phenoxyacetohydrazones

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dc.contributor.authorUlloora, S.
dc.contributor.authorShabaraya, R.
dc.contributor.authorRanganathan, R.
dc.contributor.authorVasudeva Adhikari, A.V.
dc.date.accessioned2026-02-05T09:34:56Z
dc.date.issued2013
dc.description.abstractThe present work involves design and synthesis of new substituted 1,4-dihydropyridin-4-yl-phenoxyacetohydrazones (4a-s, 5a-h), starting from 4-hydroxybenzaldehyde. The final compounds were screened for their in vivo anticonvulsant activity by MES, scPTZ and 6 Hz methods, while their anti-inflammatory screening was performed by Carrageenan induced Paw Edema method. The results indicated that compounds carrying electron donating groups are anticonvulsant active, while most of the tested compounds exhibited significant anti-inflammatory activity. Compounds 4k, l, 4p-s, and 5c showed rapid anti-inflammatory activity within 30 min and appeared as lead compounds. Further, Neurotoxicity study revealed that all the tested compounds are non-toxic up to 300 mg/kg doses. Selected compounds were also subjected to analgesic screening following Tail immersion method and they exhibited good activity. © 2013 Elsevier Masson SAS. All rights reserved.
dc.identifier.citationEuropean Journal of Medicinal Chemistry, 2013, 70, , pp. 341-349
dc.identifier.issn2235234
dc.identifier.urihttps://doi.org/10.1016/j.ejmech.2013.10.010
dc.identifier.urihttps://idr.nitk.ac.in/handle/123456789/26854
dc.publisherElsevier Masson SAS infos@masson.fr 62 rue Camille Desmoulins Issy les Moulineaux Cedex 92442
dc.subject1,4 dihydropyridin 4 yl phenoxyacetohydrazone derivative
dc.subjectanticonvulsive agent
dc.subjectantiinflammatory agent
dc.subjectcarrageenan
dc.subjectdiethyl 4 [(n' (1h indol 3 yl)methylene) 2 phenoxyacetohydrazide] 2,6 dimethyl 1,4 dihydropyridine 3,5 dicarboxylate
dc.subjectdiethyl 4 [n' ((5 methylthiophen 2 yl)methylene) 2 phenoxyacetohydrazide] 2,6 dimethyl 1,4 dihydropyridine 3,5 dicarboxylate
dc.subjectdiethyl 4 [n' (1 (1h indol 3 yl)ethylidene) 2 phenoxyacetohydrazide] 2,6 dimethyl 1,4 dihydropyridine 3,5 dicarboxylate
dc.subjectdiethyl 4 [n' (1 (4 bromophenyl)ethylidene) 2 phenoxyacetohydrazide] 2,6 dimethyl 1,4 dihydropyridine 3,5 dicarboxylate
dc.subjectdiethyl 4 [n' (1 (4 fluorophenyl)ethylidene) 2 phenoxyacetohydrazide] 2,6 dimethyl 1,4 dihydropyridine 3,5 dicarboxylate
dc.subjectdiethyl 4 [n' (1 (4 nitrophenyl)ethylidene) 2 phenoxyacetohydrazide] 2,6 dimethyl 1,4 dihydropyridine 3,5 dicarboxylate
dc.subjectdiethyl 4 [n' (1 (thiophen 2 yl)ethylidene) 2 phenoxyacetohydrazide] 2,6 dimethyl 1,4 dihydropyridine 3,5 dicarboxylate
dc.subjectdiethyl 4 [n' (1 phenylethylidene) 2 phenoxyacetohydrazide] 2,6 dimethyl 1,4 pyridine 3,5 dicarboxylate
dc.subjectdiethyl 4 [n' (2 hydroxy phenyl) 2 phenoxyacetohydrazide] 2,6 dimethyl 1,4 dihydropyridine 3,5 dicarboxylate
dc.subjectdiethyl 4 [n' (2,4 dihydroxy benzylidine) 2 phenoxyacetohydrazide] 2,6 dimethyl 1,4 dihydropyridine 3,5 dicarboxylate
dc.subjectdiethyl 4 [n' (3,4 dimethoxy benzylidine) 2 phenoxyacetohydrazide] 2,6 dimethyl 1,4 dihydropyridine 3,5 dicarboxylate
dc.subjectdiethyl 4 [n' (3,4,5 trimethoxybenzylidene) 2 phenoxyacetohydrazide] 2,6 dimethyl 1,4 dihydropyridine 3,5 dicarboxylate
dc.subjectdiethyl 4 [n' (4 bromo 2 hydroxybenzylidene) 2 phenoxyacetohydrazide] 2,6 dimethyl 1,4 dihydropyridine 3,5 dicarboxylate
dc.subjectdiethyl 4 [n' (4 bromo benzylidine) 2 phenoxyacetohydrazide] 2,6 dimethyl 1,4 dihydropyridine 3,5 dicarboxylate
dc.subjectdiethyl 4 [n' (4 chloro benzylidine) 2 phenoxyacetohydrazide] 2,6 dimethyl 1,4 dihydropyridine 3,5 dicarboxylate
dc.subjectdiethyl 4 [n' (4 dimethylamino benzylidine) 2 phenoxyacetohydrazide] 2,6 dimethyl 1,4 dihydropyridine 3,5 dicarboxylate
dc.subjectdiethyl 4 [n' (4 hydroxy 3 ethoxy benzylidine) 2 phenoxyacetohydrazide] 2,6 dimethyl 1,4 dihydropyridine 3,5 dicarboxylate
dc.subjectdiethyl 4 [n' (4 hydroxy 3 methoxy benzylidine] 2 phenoxyacetohydrazide 2,6 dimethyl 1,4 dihydropyridine 3,5 dicarboxylate
dc.subjectdiethyl 4 [n' (4 hydroxy benzylidine) 2 phenoxyacetohydrazide] 2,6 dimethyl 1,4 dihydropyridine 3,5 dicarboxylate
dc.subjectdiethyl 4 [n' (4 methyl benzylidine) 2 phenoxyacetohydrazide] 2,6 dimethyl 1,4 dihydropyridine 3,5 dicarboxylate
dc.subjectdiethyl 4 [n' (4 nitro benzylidine) 2 phenoxyacetohydrazide] 2,6 dimethyl 1,4 dihydropyridine 3,5 dicarboxylate
dc.subjectdiethyl 4 [n' (pyridin 4 yl methylene) 2 phenoxyacetohydrazide] 2,6 dimethyl 1,4 dihydropyridine 3,5 dicarboxylate
dc.subjectdiethyl 4 [n' (thiophen 2 yl methylene) 2 phenoxyacetohydrazide] 2,6 dimethyl 1,4 dihydropyridine 3,5 dicarboxylate
dc.subjectdiethyl [n' 4 ((1 hydroxynaphthalen 2 yl)methylene) 2 phenoxyacetohydrazide] 2,6 dimethyl 1,4 dihydropyridine 3,5 dicarboxylate
dc.subjecthydrazone derivative
dc.subjectunclassified drug
dc.subjectunindexed drug
dc.subjectanticonvulsant activity
dc.subjectantiinflammatory activity
dc.subjectarticle
dc.subjectcontrolled study
dc.subjectdrug design
dc.subjectdrug synthesis
dc.subjectfemale
dc.subjectimmersion
dc.subjectin vivo study
dc.subjectmale
dc.subjectmouse
dc.subjectneurotoxicity
dc.subjectnonhuman
dc.subjectpaw edema
dc.subjectrat
dc.subjectAnalgesic
dc.subjectAnti-inflammatory
dc.subjectAnticonvulsant
dc.subjectDihydropyridine
dc.subjectHydrazone
dc.subjectNeurotoxicity
dc.subjectAnimals
dc.subjectAnti-Inflammatory Agents, Non-Steroidal
dc.subjectAnticonvulsants
dc.subjectCarrageenan
dc.subjectDisease Models, Animal
dc.subjectDose-Response Relationship, Drug
dc.subjectEdema
dc.subjectElectroshock
dc.subjectFemale
dc.subjectHydrazones
dc.subjectMale
dc.subjectMice
dc.subjectMolecular Structure
dc.subjectPyridines
dc.subjectRats
dc.subjectRats, Wistar
dc.subjectSeizures
dc.titleSynthesis, anticonvulsant and anti-inflammatory studies of new 1,4-dihydropyridin-4-yl-phenoxyacetohydrazones

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