Synthesis and biological evaluation of aminoketones

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dc.contributor.authorSankappa Rai, U.
dc.contributor.authorIsloor, A.M.
dc.contributor.authorShetty, P.
dc.contributor.authorIsloor, N.
dc.contributor.authorMalladi, S.
dc.contributor.authorFun, H.-K.
dc.date.accessioned2026-02-05T09:36:06Z
dc.date.issued2010
dc.description.abstractA three-component Mannich reaction of different ketones with aromatic aldehydes and different amines in microwave irradiation under solvent free condition afforded corresponding ?-amino carbonyl compounds in excellent yields. This method proved as a novel and improved modification of the reported three-component Mannich reaction in terms of milder reaction conditions, reaction times, clean reaction profiles, very small quantity of catalyst and simple workup procedure. Newly synthesized ?-aminoketones were characterized by spectral studies. Structure of compound 4a was also confirmed by single-crystal X-ray analysis. All the compounds were screened for their antimicrobial activity by MIC method. Few of the molecules were found to be biologically potent. © 2010 Elsevier Masson SAS. All rights reserved.
dc.identifier.citationEuropean Journal of Medicinal Chemistry, 2010, 45, 12, pp. 6090-6094
dc.identifier.issn2235234
dc.identifier.urihttps://doi.org/10.1016/j.ejmech.2010.09.015
dc.identifier.urihttps://idr.nitk.ac.in/handle/123456789/27380
dc.subject2 [(2 methylindol 5 ylamino)pyridin 4 yl [methyl]]cyclohexanone
dc.subject2 [(2,4 difluorophenylamino) [2 fluoromethoxyphenyl]methyl]cyclohexanone
dc.subject2 [(2,4 difluorophenylamino) [4 fluorophenyl]methyl]cyclohexanone
dc.subject2 [(3 fluorophenylamino) [2 [allyloxy]phenyl]methyl]cyclohexanone
dc.subject2 [(3 methoxyphenylamino) [2 hydroxy 3 methylphenyl]methyl]cyclohexanone
dc.subject2 [(3,4 difluorophenylamino) (2 fluorophenyl) methyl] cyclohexanone
dc.subject2 [(3,4,5 trifluorophenylamino) (4 ethylphenyl) methyl] cyclohexanone
dc.subject2 [(4 methyl 3 nitrophenylamino) [4 ethylphenyl]methyl]cyclohexanone
dc.subject2 [(4 tert butylphenylamino) [phenyl]methyl]cyclohexanone
dc.subject2 [(benzofuran 2 yl) [naphthalen 1 ylamino]methyl]cyclohexanone
dc.subject4 [(2 chlorophenyl) [2 oxocyclohexyl]methylamino]benzonitrile
dc.subjectaldehyde
dc.subjectaminoketone
dc.subjectantiinfective agent
dc.subjectbeta aminoketone
dc.subjectunclassified drug
dc.subjectantimicrobial activity
dc.subjectarticle
dc.subjectBacillus subtilis
dc.subjectcatalyst
dc.subjectdrug screening
dc.subjectdrug structure
dc.subjectdrug synthesis
dc.subjectEscherichia coli
dc.subjectMannich reaction
dc.subjectmicrowave irradiation
dc.subjectminimum inhibitory concentration
dc.subjectPseudomonas aeruginosa
dc.subjectStaphylococcus aureus
dc.subjectX ray analysis
dc.subjectAnti-Bacterial Agents
dc.subjectCrystallography, X-Ray
dc.subjectKetones
dc.subjectMicrobial Sensitivity Tests
dc.subjectMicrowaves
dc.subjectModels, Molecular
dc.subjectMolecular Structure
dc.subjectStructure-Activity Relationship
dc.titleSynthesis and biological evaluation of aminoketones

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