Synthesis and biological evaluation of newer analogues of 2,5-disubstituted 1,3,4-oxadiazole containing pyrazole moiety as antimicrobial agents

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dc.contributor.authorMalladi, S.
dc.contributor.authorIsloor, A.M.
dc.contributor.authorPeethambar, S.K.
dc.contributor.authorFun, H.-K.
dc.date.accessioned2026-02-05T09:34:05Z
dc.date.issued2014
dc.description.abstractA series of 2,5-disubstituted-1,3,4-oxadiazole derivatives bearing pyrazole moiety were synthesized by reacting various substituted pyrazole-4-carboxylic acids with different hydrazides in POCl<inf>3</inf>. All the synthesized compounds (4a-n) were characterized by IR, NMR, mass spectra and elemental analyses. Synthesized 1,3,4-oxadiazole derivatives were screened for their antibacterial activity against three different strains, namely Escherichia coli, Staphylococcus aureus and Pseudomonas aeruginosa, while antifungal activity was determined against three different strains Aspergillus flavus, Chrysosporium keratinophilum and Candida albicans. The investigation of antimicrobial screening revealed that compounds 4i and 4j exhibited excellent activity when compared with the standard drugs. © 2013 King Saud University.
dc.identifier.citationArabian Journal of Chemistry, 2014, 7, 6, pp. 1185-1191
dc.identifier.issn18785352
dc.identifier.urihttps://doi.org/10.1016/j.arabjc.2013.12.020
dc.identifier.urihttps://idr.nitk.ac.in/handle/123456789/26439
dc.publisherElsevier B.V.
dc.subjectAspergillus
dc.subjectEscherichia coli
dc.subjectMass spectrometry
dc.subject1 , 3 , 4-oxadiazole
dc.subject1 ,3 ,4-oxadiazoles
dc.subjectAnti-bacterial activity
dc.subjectAnti-microbial activity
dc.subjectAntimicrobial screening
dc.subjectBiological evaluation
dc.subjectPseudomonas aeruginosa
dc.subjectPyrazoles
dc.subjectAntimicrobial agents
dc.titleSynthesis and biological evaluation of newer analogues of 2,5-disubstituted 1,3,4-oxadiazole containing pyrazole moiety as antimicrobial agents

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