Lipase mediated synthesis of rutin fatty ester: Study of its process parameters and solvent polarity

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dc.contributor.authorChandrasekar, C.
dc.contributor.authorBelur, P.D.
dc.contributor.authorIyyaswami, R.
dc.date.accessioned2026-02-05T09:32:07Z
dc.date.issued2017
dc.description.abstractLipophilization of antioxidants is recognized as an effective strategy to enhance solubility and thus effectiveness in lipid based food. In this study, an effort was made to optimize rutin fatty ester synthesis in two different solvent systems to understand the influence of reaction system hydrophobicity on the optimum conditions using immobilised Candida antartica lipase. Under unoptimized conditions, 52.14% and 13.02% conversion was achieved in acetone and tert-butanol solvent systems, respectively. Among all the process parameters, water activity of the system was found to show highest influence on the conversion in each reaction system. In the presence of molecular sieves, the ester production increased to 62.9% in tert-butanol system, unlike acetone system. Under optimal conditions, conversion increased to 60.74% and 65.73% in acetone and tert-butanol system, respectively. This study shows, maintaining optimal water activity is crucial in reaction systems having polar solvents compared to more non-polar solvents. © 2017 Elsevier Ltd
dc.identifier.citationFood Chemistry, 2017, 232, , pp. 278-285
dc.identifier.issn3088146
dc.identifier.urihttps://doi.org/10.1016/j.foodchem.2017.03.168
dc.identifier.urihttps://idr.nitk.ac.in/handle/123456789/25498
dc.publisherElsevier Ltd
dc.subjectAcetone
dc.subjectAlcohols
dc.subjectCandida
dc.subjectEsterification
dc.subjectEsters
dc.subjectFlavonoids
dc.subjectMolecular sieves
dc.subjectYeast
dc.subjectCandida antartica lipase
dc.subjectDifferent solvents
dc.subjectNon-polar solvents
dc.subjectOptimal conditions
dc.subjectOptimum conditions
dc.subjectProcess parameters
dc.subjectRutin
dc.subjectWater activity
dc.subjectSolvents
dc.subjectacetone
dc.subjectbutanol
dc.subjectester derivative
dc.subjectfungal enzyme
dc.subjectorganic solvent
dc.subjectrutin fatty ester
dc.subjecttriacylglycerol lipase
dc.subjectunclassified drug
dc.subjectwater
dc.subjectfungal protein
dc.subjectrutoside
dc.subjectsolvent
dc.subjectacylation
dc.subjectArticle
dc.subjectbiocatalysis
dc.subjectCandida antartica
dc.subjectcontrolled study
dc.subjectdielectric constant
dc.subjectenzyme stability
dc.subjectesterification
dc.subjecthydrolysis
dc.subjecthydrophobicity
dc.subjecttemperature
dc.subjectchemistry
dc.subjectenzymology
dc.subjectFungal Proteins
dc.subjectLipase
dc.titleLipase mediated synthesis of rutin fatty ester: Study of its process parameters and solvent polarity

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