1,3,4-Trisubstituted pyrazole bearing a 4-(chromen-2-one) thiazole: Synthesis, characterization and its biological studies

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dc.contributor.authorHarikrishna, N.
dc.contributor.authorIsloor, A.M.
dc.contributor.authorKulal, K.
dc.contributor.authorAlObaid, A.
dc.contributor.authorFun, H.-K.
dc.date.accessioned2026-02-05T09:34:02Z
dc.date.issued2015
dc.description.abstractA new series 3-{2-[N?-(1,3-disubstituted-1H-pyrazol-4-yl-methylene)-hydrazino]-thiazol-4-yl}-chromen-2-one (10a-l) was synthesized by a multi-step reaction. All the synthesized compounds were characterized by IR, NMR, and mass spectral studies, followed by elemental analysis. The newly synthesized thiazole compounds were screened for their in vitro antibacterial and antifungal studies against various microorganisms. Antimicrobial studies carried out by the well diffusion method, showed a very good zone of inhibition for both bacteria (at a range of 20-50 mm diameter) and fungi (at a range of 10-30 mm diameter). Minimum Inhibitory Concentration (MIC) required for the 100% inhibition of bacteria and fungi was found to be as low as 15.6 ?g ml-1 for a few of the synthesized compounds. © The Royal Society of Chemistry 2015.
dc.identifier.citationRSC Advances, 2015, 5, 54, pp. 43648-43659
dc.identifier.urihttps://doi.org/10.1039/c5ra04995d
dc.identifier.urihttps://idr.nitk.ac.in/handle/123456789/26399
dc.publisherRoyal Society of Chemistry
dc.subjectFungi
dc.subjectMicroorganisms
dc.subjectSpectroscopic analysis
dc.subjectSynthesis (chemical)
dc.subjectAntimicrobial study
dc.subjectBiological studies
dc.subjectChromen-2-one
dc.subjectDiffusion method
dc.subjectMass spectral
dc.subjectMinimum inhibitory concentration
dc.subjectMultistep reactions
dc.subjectZone of inhibitions
dc.subjectBacteria
dc.title1,3,4-Trisubstituted pyrazole bearing a 4-(chromen-2-one) thiazole: Synthesis, characterization and its biological studies

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